Effects of Oriental medicines on the production of advanced glycation endproducts
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概要
- 論文の詳細を見る
advanced glycation endproducts(AGE)は糖尿病性腎症の成因に大きく関与しており,AGE生成の抑制が腎症発症・進展防止に重要であることが知られている。このことから,本研究ではAGE阻害薬の可能性を和漢薬に求め,in vitroの評価系で検討した。使用した漢方方剤12種類のうち,最もAGE生成を抑制した漢方方剤は温脾湯で,次いで桃核承気湯,桂枝茯苓丸,大黄牡丹皮湯の順であった。実験に供した21種類の構成生薬では大黄,桂皮,牡丹皮,芍薬に強い抑制作用を認め,大黄剤,駆〓血剤ならびにタンニン生薬がAGEの生成を抑制しているものと考えられた。またこれらは陽性対照物質のアミノグアニジンより強い活性を示した。
- 和漢医薬学会の論文
- 2001-06-20
著者
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Yokozawa Takako
Institute of Natural Medicine, University of Toyama
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TERASAWA Katsutoshi
Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical Uni
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NAKAGAWA Takako
Department of Kampo Diagnostics, Institute of Natural Medicine, University of Toyama
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横澤 隆子
富山大学和漢医薬学総合研究所
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Yokozawa Takako
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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横澤 隆子
Institute of Natural Medicine
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Nakagawa Takako
Department Of Japanese Oriental Medicine Toyama Medical And Pharmaceutical University
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Nakagawa Takako
Department Of Anesthesia Ntt West Hospital
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Terasawa Katsutoshi
Department Of Japanese Oriental (kampo) Medicine Faculty Of Medicine Toyama Medical And Pharmaceutic
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Terasawa Katsutoshi
Department Of Integrated Japanese Oriental Medicine School Of Medicine Gunma University
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