Inhibitory effects of Cinnamomi Cortex and cinnamaldehyde on oxygen-derived free radical-induced vasocontraction in isolated aorta of spontaneously hypertensive rats
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概要
- 論文の詳細を見る
自然発症高血圧ラット(SHR)摘出胸部大動脈におけるキサンチン-キサンチンオキシダーゼ(XOD)誘発血管収縮反応に対する桂皮エキスおよびケイヒアルデヒド(CA)の収縮抑制作用についてオルガンバス法を用いて検討した。キサンチン-XOD誘発血管収縮反応は,SHR対照群と比較して,桂皮エキス(10^<-4>g/ml)前処置群,CA(10^<-4>M)前処置群で,有意に抑制されていた。キサンチン-XOD収縮反応時のトロンボキサンB_2(TXB_2)産生量は,SHR対照群と比較して,桂皮エキス(10^<-4>g/ml)群,CA(10^<-4>M)群で,有意に抑制されていた。CAのTX産生抑制の機序を検討するため,フォスフォリパーゼA_2(PLA_2)誘発血管収縮反応に対する収縮抑制作用について検討したところ,PLA_2誘発血管収縮反応はSHR対照群と比較して,CA(10^<-4>M)群で,有意に抑制されていた。PLA_2収縮反応時のTXB_2産生量は,SHR対照群と比較してCA(10^<-4>M)群で,有意に抑制されていた。以上のことから,桂皮は,血管収縮因子であるTXA_2抑制作用を持つ生薬である可能性が示唆された。
- 和漢医薬学会の論文
- 2002-04-20
著者
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TERASAWA Katsutoshi
Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical Uni
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Terasawa Katsutoshi
群馬大学 医学部医学科統合和漢診療学講座
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SEKIYA Nobuyasu
Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical Uni
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SHIMADA Yutaka
Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical Uni
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Terasawa K
Dept. Of Japanese Oriental Medicine Graduate School Of Medicine Chiba University
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GOTO Hirozo
Department of Kampo Diagnostics, Institute of Natural Medicine, Toyama Medical and Pharmaceutical Un
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Shimada Y
Dept. Of Japanese Oriental Medicine Faculty Of Medicine University Of Toyama
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Goto Hirozo
Toyama Medical and Pharmaceutical University
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Goto H
Department Of Japanese Oriental Medicine Faculty Of Medicine University Of Toyama
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Goto Hirozo
富山大学 大学院医学薬学研究部和漢診療学講座
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Goto Hirozo
Department Of Kampo Diagnostics Institute Of Natural Medicine University Of Toyama
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Shimada Y
Tokyo Inst. Technol. Yokohama Jpn
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Shimada Yuji
Microsystem Research Center Precision And Intelligence Laboratory Tokyo Institute Of Technology
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Shimada Y
Tohoku Univ. Sendai Jpn
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島田 洋蔵
産業技術総合研究所
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YANG Qiao
Department of Traditional Chinese Medicine, General Hospital, Tianjin Medical University
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Goto Hirozo
Department Of Japanese Oriental Medicine Faculty Of Medicine University Of Toyama
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Sekiya Nobuyasu
Department Of Japanese Oriental Medicine Faculty Of Medicine
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嶋田 豊
富山医科薬科大学医学部和漢診療学
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Shibahara Naotoshi
Department Of Kampo Diagnostics Institute Of Natural Medicine University Of Toyama : 21st Century Co
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KASAHARA Yuji
Department of Japanese Oriental (Kampo) Medicine, Toyama Medical and Pharmaceutical University
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Yang Q
Department Of Traditional Chinese Medicine General Hospital Tianjin Medical University
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Yang Qiao
Department Of Biochemistry And Molecular Biology College Of Basic Medical Sciences Second Military M
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Goto Hirozo
Department Of Japanese Oriental Medicine Faculty Of Medicine University Of Toyama : 21st Century Coe
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Sekiya N
Department Of Japanese Oriental Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical Unive
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島田 洋蔵
Dept. Of Japanese Oriental Medicine Faculty Of Medicine University Of Toyama
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Shimada Yutaka
Department Of Anatomy And Cell Biology School Of Medicine Chiba Unversity
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Terasawa Katsutoshi
Department Of Japanese Oriental Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical Unive
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Shimada Yutaka
21^<st> Century Coe Program Toyama Medical And Pharmaceutical University
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Kasahara Yuji
Department Of Japanese Oriental (kampo) Medicine Toyama Medical And Pharmaceutical University
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Kasahara Yuji
Department Of Information Sciences Faculty Of Science Ochanomizu University
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Shimada Nobuyasu
Department Of Japanese Oriental Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical Unive
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Terasawa Katsutoshi
Department Of Japanese Oriental (kampo) Medicine Faculty Of Medicine Toyama Medical And Pharmaceutic
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Shimada Yutaka
Department Of Anatomy And Cell Biology School Of Medicine Chiba University
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Terasawa Katsutoshi
Department Of Integrated Japanese Oriental Medicine School Of Medicine Gunma University
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