Inhibitory Effects of Triterpenes Isolated from Chuling (Polyporus umbellatus FRIES) on Free Radical-Induced Lysis of Red Blood Cells(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
Chuling, sclerotia of Polyporus umbellatus FRIES, has long been used for urological disorders in traditional medicine. In this study, we demonstrated that Chuling in vitro protects red blood cells from 2,2-azo-bis(2-amidinopropane)dihydrochloride (AAPH)-induced hemolysis. The inhibitory effect was dose-dependent at concentrations of 50 to 1000μg/ml. Moreover, tests were carried out to identify the main ingredient of Chuling with scavenging effect on free radicals. Triterpene carboxylic acids isolated from the methanol extract of Chuling, namely, polyporusterone A and polyporusterone B, were found to have inhibitory activities against AAPH-induced lysis of red blood cells. The anti-hemolytic effect was significantly stronger in polyporusterone B compared with polyporusterone A. Furthermore, the ingestion of 150mg of Chuling was associated with a significant increase in free-radical scavenging effect of plasma in rats.
- 社団法人日本薬学会の論文
- 2005-05-01
著者
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Terasawa Katsutoshi
群馬大学 医学部医学科統合和漢診療学講座
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Nakai Yoichiro
Central Research Laboratories Tsumura & Co.
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Nakai Yoichiro
Pharmacognosy & Medicinal Resources Laboratory Tsumura & Co.
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SEKIYA Nobuyasu
Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical Uni
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HIKIAMI Hiroaki
Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical Uni
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SAKAKIBARA Iwao
Pharmacognosy & Medicinal Resources Laboratory, Tsumura & Co.
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NOZAKI Kazuya
Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical Uni
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KOUTA Kazufumi
Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical Uni
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SHIMADA Yutaka
Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical Uni
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TERASAWA Katsutoshi
21st Century COE Program, Toyama Medical and Pharmaceutical University
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Terasawa K
Dept. Of Japanese Oriental Medicine Graduate School Of Medicine Chiba University
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寺澤 捷年
富山医科薬科大・和漢診療学教室
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Shimada Y
Dept. Of Japanese Oriental Medicine Faculty Of Medicine University Of Toyama
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Shimada Y
Tokyo Inst. Technol. Yokohama Jpn
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Kita T
Department Of Integrated Japanese Oriental Medicine School Of Medicine Gunma University
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Shimada Y
Institute Of Multidisciplinary Research For Advanced Materials Tohoku University
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Shimada Yuji
Microsystem Research Center Precision And Intelligence Laboratory Tokyo Institute Of Technology
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Shimada Y
Tohoku Univ. Sendai Jpn
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島田 洋蔵
産業技術総合研究所
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Sekiya Nobuyasu
Department Of Japanese Oriental Medicine Faculty Of Medicine
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嶋田 豊
富山医科薬科大学医学部和漢診療学
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Shibahara Naotoshi
Department Of Kampo Diagnostics Institute Of Natural Medicine University Of Toyama : 21st Century Co
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Nozaki Kazuya
Department Of Japanese Oriental Medicine Faculty Of Medicine University Of Toyama
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Kouta Kazufumi
Department Of Japanese Oriental Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical Unive
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Terasawa Katsutoshi
21st Century Coe Program University Of Toyama:department Of Japanese Oriental Medicine Graduate Scho
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Sakakibara I
Pharmacognosy And Medicinal Resources Research Department Tsumura And Co.
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Sakakibara Iwao
Tsumura & Co. Ibaraki Jpn
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Kita T
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Sekiya N
Department Of Japanese Oriental Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical Unive
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Hikiami Hiroaki
富山大学 大学院医学薬学研究部和漢診療学講座
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Hikiami Hiroaki
Department Of Japanese Oriental Medicine Graduate School Of Medical And Pharmaceutical Sciences Univ
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Shibagaki Yukari
富山大学和漢医薬学総合研究所
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島田 洋蔵
Dept. Of Japanese Oriental Medicine Faculty Of Medicine University Of Toyama
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Shimada Yutaka
Department Of Anatomy And Cell Biology School Of Medicine Chiba Unversity
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Shimada Yutaka
21^<st> Century Coe Program Toyama Medical And Pharmaceutical University
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Terasawa Katsutoshi
21st Century Coe Program University Of Toyama
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Shimada Nobuyasu
Department Of Japanese Oriental Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical Unive
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Nakamura Yuichi
Pharmacognosy & Medicinal Resources Research Department
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Shimada Yutaka
Department Of Anatomy And Cell Biology School Of Medicine Chiba University
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HIKIAMI Hiroaki
Department of Japanese Oriental (Kampo) Medical Center, Suwa Central Hospital
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