Metabolic Fate of Ulinastatin (2); Pharmacokinetics in Rabbits Following Intra-Articular Administration
スポンサーリンク
概要
- 論文の詳細を見る
The absorption and distribution of ulinastatin following intra-articular administration of [^<125>I]ulinastatin to rabbits were determined and kinetic analysis using a multi-compartment model was performed. At 4h after administration, the content of radioactivity in the synovial fluid, which was comparable to that of the immunoreactive ulinastatin, was 14.51% of the dose and decreased in a biphasic manner. The highest level of radioactivity was observed in the synovial membrane, followed by the meniscus, ligament, cartilage and patella, the radioactivities of whcih also declined biphasically. After intra-articular administration, the plasma concentration of total radioactivity increased slowly and reached maximum at 4.3 h, and then declined slowly in a monophasic manner with a half-life of 10.8 h. The radioactivity of the high molecular weight fraction in plasma, which reached maximum at 1.7 h after administration and then declined with a half-life of 11.8 h, was consistent with the time curve for immunoreactive ulinastatin in the plasma through 24 h after the administration. Within 8 and 24 h after administration, respectively, 1.48 and 4.66% of the administered radioactivity were transferred to the lymphatic fluid. The pharmacokinetics of[^<125>I]ulinastatin after an intra-articular administration could be explained using a multi-compartment model in which a portion of the administered ulinastatin was absorbed via the lymphatic system. This finding suggested that ulinastatin was rapidly distributed and retained for a long period of time in the joint tissues. In addition, the pharmacokinetics of ulinastatin following intra-articular administration indicated typical flip-flop kinetics.
- 公益社団法人日本薬学会の論文
- 1997-07-15
著者
-
Nakai Yoichiro
Central Research Laboratories Tsumura & Co.
-
Nakai Yoichiro
東北大学 薬研究 分子生物薬
-
Nakai Yasuhiro
Fuji Central Research Laboratory Mochida Pharmaceutical Co. Ltd.
-
OHZAWA Nobuo
Fuji Central Research Laboratory, Mochida Pharmaceutical Co., Ltd.,
-
TAKAHASHI Yasuo
Fuji Central Research Laboratory, Mochida Pharmaceutical Co., Ltd.,
-
OGIHARA Takuo
Fuji Central Research Laboratory, Mochida Pharmaceutical Co., Ltd.,
-
ISHIGURO Junzoh
Fuji Central Research Laboratory, Mochida Pharmaceutical Co., Ltd.,
-
Takahashi Y
Analytical Instruments Division Jeol Ltd.
-
Nakai Y
Central Research Laboratories Tsumura & Co.
-
Ogihara T
Fuji Central Research Laboratory Mochida Pharmaceutical Co. Ltd.
-
Ohzawa Nobuo
Drug Metabolism And Pharmacokinetics Laboratory Research Center Mochida Pharmaceutical Co. Ltd
-
Ishiguro Junzo
Fuji Central Research Laboratory Mochida Pharmaceutical Co. Ltd.
-
Takahashi Yasuo
Fuji Central Research Laboratory Mochida Pharmaceutical Co. Ltd.
関連論文
- Inhibitory Effects of Triterpenes Isolated from Chuling (Polyporus umbellatus FRIES) on Free Radical-Induced Lysis of Red Blood Cells(Pharmacology)
- An Herbal Medicine Orengedokuto Prevents Indomethacin-Induced Enteropathy(Pharmacology)
- Effects of Saireito, a Japanese herbal medicine, on edema via antagonistic actions against aldosterone in anti-GBM nephritic rats
- Effects of Rikkunshi-to, a Traditional Japanese Medicine, on the Delay of Gastric Emptying Induced by N^G-Nitro-L-arginine
- Effects of Rikkunshi-to, a Traditional Japanese Medicine, on the Delay of Gastric Emptying Induced by NG-Nitro-L-arginine
- Pharmacological Evaluation of Shokyo and Kankyo (1)
- Separation and isolation methods for analysis of the active principles of Sho-saiko-to (SST) oriental medicine
- Physicochemical quality evaluation of natural compounds isolated from crude drugs : Standard compounds for the official specification and testing method of "Processed Aconite Root" and "Powdered Processed Aconite Root" in the Japanese Pharmacopoeia
- Structure-Activity Relationship(SAR)Studies on Oxazolidinone Antibacterial Agents.3.^ Synthesis and Evaluation of 5-Thiocarbamate Oxazolidinones
- Structure-Activity Relationship(SAR)Studies on Oxazolidinone Antibacterial Agents.2.^ Relationship between Lipophilicity and Antibacterial Activity in 5-Thiocarbonyl Oxazolidinones
- Structure-Activity Relationship(SAR)Studies on Oxazolidinone Antibacterial Agents.1. Conversion of 5-Substituent on Oxazolidinone
- Studies on Macrolide Antibiotics I. Synthesis and Antibacterial Activity of Erythromycin A 9-O-Substituted Oxime Ether Derivatives against Mycobacterium avium Complex
- Functional Modification of Cytochrome c by Peroxynitrite in an Electron Transfer Reaction
- Metabolic Fate of Ulinastatin (2); Pharmacokinetics in Rabbits Following Intra-Articular Administration
- PHARMACOKINETIC STUDY OF ULINASTATIN AFTER INTRA-ARTICULAR ADMINISTRATION TO RABBITS
- A New Acetylenic Compound from the Rhizomes of Atractylodes chinensis and Its Absolute Configuration
- Antagonism of Saikosaponin-Induced Prostaglandin E_2 Release by Baicalein in C6 Rat Glioma Cells
- Quantitative Taste Evaluation of Total Enteral Nutrients
- Bitterness Evaluation of Medicines for Pediatric Use by a Taste Sensor
- Effect of Pore Size on the Gaseous Adsorption of Ethenzamide on Porous Crystalline Cellulose and the Physicochemical Stability of Ethenzamide after Storage
- Freeze-Drying of Drug-Oligosaccharide Binary System
- Determination of Solubility Parameters for Solid Medicinals and Excipients
- STUDY OF FREEZE-DRYING IN DRUG-ADDITIVE BINARY SYSTEM
- POSSIBLE MECHANISM BEHIND THE INTERACTIONS BETWEEN POROUS POWDER AND CRYSTALLINE MEDICINALS
- Studies on the Metabolic Fate of M17055, a Novel Diuretic (5): Pharmacokinetics and Pharmacodynamics of Unchanged Drug in Rat and Dog After Intravenous Administration of M17055
- Studies on the Metabolic Fate of M17055, a Novel Diuretic (4) : Species Difference in Metabolic Pathway and Identification of Human CYP Isoform Responsible for the Metabolism of M17055
- POLYMORPHISM OF TEGAFUR
- BEHAVIOUR OF MEDICINAL MOLECULES IN THE INCLUSION COMPOUNDS OR GROUND MIXTURES WITH CYCLODEXTRINS
- PHYSICOCHEMICAL PROPERTIES OF TRI-O-METHYL-β-CYCLODEXTRIN AND ITS INTERACTIONS WITH DRUGS
- Metabolic Disposition of Ethyl Eicosapentaenoate and Its Metabolites in Rats and Dogs