Metabolic Disposition of Ethyl Eicosapentaenoate and Its Metabolites in Rats and Dogs

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概要

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• When orally administered to rats, ^<14>C-labelled ethyl eicosapentaenoate (^<14>C-EPA-E) was hydrolyzed and, in the lymph, incorporated mainly into triglycerides (TG) in chylomicrons. In plasma and other tissues, eicosapentaenoic acid (EPA) and its metabolites, such as docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA), were detected in TG and phospholipid fractions. In plasma, EPA and its metabolites were found to be integrated into lipoproteins. Tissue distribution of these metabolites showed characteristic patterns from one tissue to another, as did their compositional distribution in lipids. EPA, DPA and DHA were found to be metabolized via β-oxidation in in vitro experiments with mitochondrial fraction.

• 公益社団法人日本薬学会の論文

著者

• OHZAWA Nobuo

  Fuji Central Research Laboratory, Mochida Pharmaceutical Co., Ltd.,

• OGIHARA Takuo

  Fuji Central Research Laboratory, Mochida Pharmaceutical Co., Ltd.,

• ISHIGURO Junzo

  Fuji Central Research Laboratory, Mochida Pharmaceutical Co., Ltd. 722

• Ogihara T

  Fuji Central Research Laboratory Mochida Pharmaceutical Co. Ltd.

• Ohzawa Nobuo

  Drug Metabolism And Pharmacokinetics Laboratory Research Center Mochida Pharmaceutical Co. Ltd

• Ishiguro Junzo

  Fuji Central Research Laboratory Mochida Pharmaceutical Co. Ltd.

• Kosuzume Hiroshi

  Fuji Central Research Laboratory Mochida Pharmaceutical Co. Ltd.

• TADA Toshito

  Fuji Central Research Laboratory, Mochida Pharmaceutical Co., Ltd.

• MURAKAMI Kimihiro

  Fuji Central Research Laboratory, Mochida Pharmaceutical Co., Ltd.

• Tada Toshito

  Fuji Central Research Laboratory Mochida Pharmaceutical Co. Ltd.

• Murakami Kimihiro

  Fuji Central Research Laboratory Mochida Pharmaceutical Co. Ltd.

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• Metabolic Disposition of Ethyl Eicosapentaenoate and Its Metabolites in Rats and Dogs

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