Inhibitory Effects of Stephania tetrandra S. MOORE on Free Radical-Induced Lysis of Rat Red Blood Cells(Pharmacognosy)

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概要

• 論文の詳細を見る

• Crude preparations of Stephania tetrandra S. MOORE (ST), a traditional herbal medicine, have been used safely for arthritis and silicosis in China. In this study, we demonstrated that ST in vitro protects red blood cells from 2, 2-azo-bis (2-amidinopropane) dihydrochloride (AAPH)-induced hemolysis. The inhibitory effect was dose-dependent at concentrations of 10 to 1000μg/ml. Moreover, tests were carried out to identify the main ingredient of ST that exerts a scavenging effect on free-radicals. Three representative alkaloids, tetrandrine, fangchinoline, and cyclanoline, isolated from ST, were found to have inhibitory activities against AAPH-induced lysis of red blood cells (RBC). Furthermore, the ingestion of 200 mg of ST extract was associated with a significant increase in free-radical scavenging effect of plasma in rats. These results suggest that ST as antioxidant inhibits AAPH-induced hemolysis of RBC both in vitro and in vivo.

• 社団法人日本薬学会の論文
• 2005-04-01

著者

• Terasawa Katsutoshi

  群馬大学 医学部医学科統合和漢診療学講座

• SEKIYA Nobuyasu

  Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical Uni

• HIKIAMI Hiroaki

  Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical Uni

• SAKAKIBARA Iwao

  Pharmacognosy & Medicinal Resources Laboratory, Tsumura & Co.

• KOUTA Kazufumi

  Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical Uni

• SHIMADA Yutaka

  Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical Uni

• TERASAWA Katsutoshi

  21st Century COE Program, Toyama Medical and Pharmaceutical University

• Terasawa K

  Dept. Of Japanese Oriental Medicine Graduate School Of Medicine Chiba University

• 寺澤 捷年

  富山医科薬科大・和漢診療学教室

• Shimada Y

  Dept. Of Japanese Oriental Medicine Faculty Of Medicine University Of Toyama

• YOKOYAMA Koichi

  Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical Uni

• Shimada Y

  Tokyo Inst. Technol. Yokohama Jpn

• Kita T

  Department Of Integrated Japanese Oriental Medicine School Of Medicine Gunma University

• Shimada Y

  Institute Of Multidisciplinary Research For Advanced Materials Tohoku University

• 寺澤 捷年

  富山医科薬科大学和漢診療学講座

• Shimada Yuji

  Microsystem Research Center Precision And Intelligence Laboratory Tokyo Institute Of Technology

• Shimada Y

  Tohoku Univ. Sendai Jpn

• 島田 洋蔵

  産業技術総合研究所

• Sekiya Nobuyasu

  Department Of Japanese Oriental Medicine Faculty Of Medicine

• 嶋田 豊

  富山医科薬科大学医学部和漢診療学

• Shibahara Naotoshi

  Department Of Kampo Diagnostics Institute Of Natural Medicine University Of Toyama : 21st Century Co

• Kouta Kazufumi

  Department Of Japanese Oriental Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical Unive

• Terasawa Katsutoshi

  21st Century Coe Program University Of Toyama:department Of Japanese Oriental Medicine Graduate Scho

• Sakakibara I

  Pharmacognosy And Medicinal Resources Research Department Tsumura And Co.

• Sakakibara Iwao

  Tsumura & Co. Ibaraki Jpn

• Yokoyama Koichi

  Department Of Cardiology Pulmonology And Nephrology Yamagata University School Of Medicine

• Kita T

  Toyama Medical And Pharmaceutical Univ. Toyama Jpn

• Sekiya N

  Department Of Japanese Oriental Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical Unive

• Hikiami Hiroaki

  富山大学 大学院医学薬学研究部和漢診療学講座

• Hikiami Hiroaki

  Department Of Japanese Oriental Medicine Graduate School Of Medical And Pharmaceutical Sciences Univ

• Shibagaki Yukari

  富山大学和漢医薬学総合研究所

• 島田 洋蔵

  Dept. Of Japanese Oriental Medicine Faculty Of Medicine University Of Toyama

• 寺澤 捷年

  千葉大学 大学院医学研究院和漢診療学講座

• Shimada Yutaka

  Department Of Anatomy And Cell Biology School Of Medicine Chiba Unversity

• Shimada Yutaka

  21^<st> Century Coe Program Toyama Medical And Pharmaceutical University

• Terasawa Katsutoshi

  21st Century Coe Program University Of Toyama

• Yokoyama Koichi

  Department Of Japanese Oriental Medicine Faculty Of Medicine

• Shimada Nobuyasu

  Department Of Japanese Oriental Medicine Faculty Of Medicine Toyama Medical And Pharmaceutical Unive

• Shimada Yutaka

  Department Of Anatomy And Cell Biology School Of Medicine Chiba University

• HIKIAMI Hiroaki

  Department of Japanese Oriental (Kampo) Medical Center, Suwa Central Hospital

• Yokoyama Koichi

  Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University

• YOKOYAMA Koichi

  Depart-ment of Internal Medicne Yamagata Prefectural Central Hospital

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