Effects of Eppikahangeto, a Kampo Formula, and Ephedrae herba Against Citric Acid-Induced Laryngeal Cough in Guinea Pigs
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概要
- 論文の詳細を見る
To evaluate the efficacy of three common antitussive Kampo formulas, eppikahangeto (EPP), bakumondoto (BAK), and shoseiryutogomakyokansekito (SGM), a new cough model of guinea pig was used, which could specifically induce a laryngeal cough by microinjection of citric acid solution into the larynx. Kampo extract was dissolved in water and the animals were given access ad libitum for 3 days, and then the number of coughs during 10 min was counted. EPP extract decreased the number of coughs dose-dependently (0.3% extract, −22.9 ± 6.6%, P<0.01; 1.0% extract, −32.4 ± 5.5%, P<0.01). BAK extract and SGM extract had no significant effect. Intraperitoneal injection of codeine (60 mg/kg) also decreased the number of coughs (−36.1 ± 9.1%, P<0.05). Furthermore, Ephedrae herba (EH) extract reduced the number of coughs (−18.3 ± 6.0%, P<0.05), but the extract of EPP without EH did not. These results suggest that EPP has an antitussive effect against laryngeally-induced cough in guinea pigs, and the crucial herbal medicine is EH.
- 社団法人 日本薬理学会の論文
- 2006-06-20
著者
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寺澤 捷年
富山医科薬科大学
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Terasawa Katsutoshi
富山医科薬科大学和漢薬研究所
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Terasawa Katsutoshi
群馬大学 医学部医学科統合和漢診療学講座
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SHIMADA Yutaka
Department of Japanese Oriental Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical Uni
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TERASAWA Katsutoshi
21st Century COE Program, Toyama Medical and Pharmaceutical University
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Terasawa K
Dept. Of Japanese Oriental Medicine Graduate School Of Medicine Chiba University
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GOTO Hirozo
Department of Kampo Diagnostics, Institute of Natural Medicine, Toyama Medical and Pharmaceutical Un
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Shimada Y
Dept. Of Japanese Oriental Medicine Faculty Of Medicine University Of Toyama
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Goto Hirozo
Toyama Medical and Pharmaceutical University
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Goto H
Department Of Japanese Oriental Medicine Faculty Of Medicine University Of Toyama
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Goto Hirozo
富山大学和漢医薬学総合研究所 病態生化学
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Goto Hirozo
富山大学 大学院医学薬学研究部和漢診療学講座
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Goto H
富山医科薬科大学和漢薬研究所漢方診断学部門
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Goto Hirozo
Department Of Kampo Diagnostics Institute Of Natural Medicine University Of Toyama
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Shimada Y
Tokyo Inst. Technol. Yokohama Jpn
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Kita T
Department Of Integrated Japanese Oriental Medicine School Of Medicine Gunma University
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Shimada Y
Institute Of Multidisciplinary Research For Advanced Materials Tohoku University
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Shimada Yuji
Microsystem Research Center Precision And Intelligence Laboratory Tokyo Institute Of Technology
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Shimada Y
Tohoku Univ. Sendai Jpn
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MINAMIZAWA Kiyoshi
Department of Japanese Oriental Medicine, Faculty of Medicine, University of Toyama
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HAJI Akira
Laboratory of Neuropharmacology, School of Pharmacy, Aichi Gakuin University
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島田 洋蔵
産業技術総合研究所
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Goto Hirozo
Department Of Japanese Oriental Medicine Faculty Of Medicine University Of Toyama
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嶋田 豊
富山医科薬科大学医学部和漢診療学
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Haji Akira
Laboratory Of Neuropharmacology School Of Pharmacy Aichi Gakuin University
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後藤 博三
富山医科薬科大学和漢薬研究所漢方診断学部門
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Terasawa Katsutoshi
21st Century Coe Program University Of Toyama:department Of Japanese Oriental Medicine Graduate Scho
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Goto Hirozo
Department Of Japanese Oriental Medicine Faculty Of Medicine University Of Toyama : 21st Century Coe
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Kita T
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Shibagaki Yukari
富山大学和漢医薬学総合研究所
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島田 洋蔵
Dept. Of Japanese Oriental Medicine Faculty Of Medicine University Of Toyama
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Shimada Yutaka
Department Of Anatomy And Cell Biology School Of Medicine Chiba Unversity
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Shimada Yutaka
21^<st> Century Coe Program Toyama Medical And Pharmaceutical University
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Terasawa Katsutoshi
21st Century Coe Program University Of Toyama
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Shimada Yutaka
Department Of Anatomy And Cell Biology School Of Medicine Chiba University
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Minamizawa Kiyoshi
Department Of Japanese Oriental Medicine Faculty Of Medicine University Of Toyama
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