Beneficial Effects of Sanguisorbae Radix in Renal Dysfunction Caused by Endotoxin in Vivo
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概要
- 論文の詳細を見る
The effect of Sanguisorbae Radix extract, a traditional crude drug, was investigated in renal dysfunction induced by lipopolysaccharide (LPS) endotoxin. Injection of LPS in rats resulted in a sharp rise in the serum levels of urea nitrogen and creatinine (Cr), indicating impairment of renal function. Nitrite and nitrate levels and the activity of inducible nitric oxide synthase (iNOS), an enzyme which participates in NO synthesis, were also significantly increased in the serum of LPS-treated rats compared with normal rats. In rats pretreated with Sanguisorbae Radix extract, renal dysfunction was attenuated and the increases in serum urea nitrogen and Cr induced by LPS were significantly reduced. The administration of Sanguisorbae Radix extract also effectively lowered serum nitrite/nitrate level. A similar effect was observed on the iNOS activity. These results indicate that Sanguisorbae Radix extract contributes to the regulation of renal function under conditions where there is excessive generation of NO.
- 公益社団法人日本薬学会の論文
- 1999-12-15
著者
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Yokozawa Takako
Institute of Natural Medicine, University of Toyama
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Yokozawa Takako
富山医科薬科大学和漢医薬学総合研究所
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Chen C
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Yokozawa T
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Yokozawa Takako
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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KITANI Kenichi
National Institute for Longevity Sciences
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CHEN Cui
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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Chen Cui
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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横澤 隆子
Inst. Of Natural Medicine Univ. Of Toyama
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Kitani K
National Institute For Longevity Sciences
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