Anti-aging Effects of Cyanidin under a Stress-Induced Premature Senescence Cellular System
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概要
- 論文の詳細を見る
The anti-aging effects of cyanidin were investigated under stress-induced premature senescence (SIPS) using WI-38 human diploid fibroblasts. WI-38 cells that were treated with 300 μM H2O2 showed losses of cell viability, increased lipid peroxidation, and shortened cell lifespans. However, treatment with cyanidin attenuated cellular oxidative stress through increase of cell viability and the inhibition of lipid peroxidation. In addition, the life spans of young-, middle-, and old-aged WI-38 cells were prolonged by cyanidin treatment. Furthermore, H2O2-treated WI-38 cells significantly increased mRNA and protein expressions of nuclear factor-κB, cyclooxygenase-2, and inducible nitric oxide synthase, while those treated with cyanidin had significantly decreased expressions. These results suggest that cyanidin may delay the aging process by attenuating oxidative stress under the SIPS cellular model.
- 日本薬学会の論文
著者
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Yokozawa Takako
Institute of Natural Medicine, University of Toyama
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Kim Boh
Department of Food Science and Nutrition, Pusan National University
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Choi Mi
Department of Food Science and Nutrition, Pusan National University
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Park Kun
Department of Food Science and Nutrition, Pusan National University
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Cho Eun
Department Of Food Science And Nutrition Pusan National University
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SONG Young
Department of Internal Medicine and AIDS Research Institute, Yonsei University College of Medicine
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Choi Mi
Department Of Chemistry Chung-ang University
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Yokozawa Takako
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Song Young
Department Of Animal Resources Technology Jinju National University
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Cho Eun
Department Of Chemistry Yeungnam University
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Song Young
Department of Food Science and Nutrition, Research Institute of Ecology for the Elderly, Pusan National University
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Choi Mi
Department of Food Science and Nutrition, Research Institute of Ecology for the Elderly, Pusan National University
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Cho Eun
Department of Food Science and Nutrition, Research Institute of Ecology for the Elderly, Pusan National University
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CHO Eun
Department of Animal Science and Biotechnology, Gyeongnam National University of Science and Technology
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Kim Boh
Department of Food Science and Nutrition, Research Institute of Ecology for the Elderly, Pusan National University
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