Mustard Leaf Suppresses Nitric Oxide Synthesis by Mouse Macrophages
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概要
- 論文の詳細を見る
The effect of mustard leaf on nitric oxide (NO) production was investigated using lipopolysaccharide (LPS)-stimulated peritoneal macrophages. LPS induced the production of a large amount of nitrite, an indicator of NO. However, the addition of the ethylacetate (EtOAc) or n-butanol (BuOH) fraction of mustard leaf to LPS-stimulated peritoneal macrophages inhibited excessive production of nitrite significantly. Moreover, compared with no treatment, LPS impaired cell viability significantly. However, the EtOAc fraction of mustard leaf significantly protected cells that had been exposed to LPS. In addition, the result of nitrite production per cell indicated that the mustard leaf fractions significantly suppressed nitrite synthesis by macrophages. In particular, the EtOAc fraction was a stronger inhibitor of nitrite synthesis than the BuOH fraction. As NO is one of the critical mediators in various disorders, these results may help to explain certain pharmacological activities of mustard leaf.
- 日本ビタミン学会の論文
著者
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Yokozawa Takako
Institute of Natural Medicine, University of Toyama
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Yokozawa Takako
Inst. Of Natural Medicine Univ. Of Toyama
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Yoshikawa T
Institute Of Natural Medicine University Of Toyama
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KIM Hyun
Institute of Natural Medicine, University of Toyama
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CHO Eun
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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Kim Hyun
Dep. Of Food Sci. Jinju National Univ.
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Cho E
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Yokozawa Takako
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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CHO Eun
富山医科薬科大学和漢薬研究所
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Kim Hyun
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Kim Hyun
Univ. Toyama Toyama Jpn
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横澤 隆子
Inst. Of Natural Medicine Univ. Of Toyama
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Kim H
Univ. Toyama Toyama Jpn
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Cho Eun
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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KIM Hyun
Institute of Musculoskeletal Aging, Hallym University
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