Hypolipidemic Effects of Sophora flavescens and Its Constituents in Poloxamer 407-Induced Hyperlipidemic and Cholesterol-Fed Rats(Pharmacognosy)

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概要

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• In this study, we investigated the hypolipidemic effects of Sophora flavescens in poloxamer 407-induced hyperlipidemic and cholesterol-fed rats. The MeOH extract and 4 fractions of S. flavescens were administered at doses of 250 and 100mg/kg body weight, respectively, once a day for 3 d to the poloxamer 407-induced hyperlipidemic rats. Serum lipid levels such as total cholesterol (TC), triglycerides (TG), and low-density lipoprotein-cholesterol (LDL-C) were markedly elevated in the poloxamer 407-induced hyperlipidemic control rats, while lipid levels were significantly decreased in the rats administered the MeOH extract or 4 fractions of S. flavescens. In addition, serum high-density lipoprotein-cholesterol (HDL-C) was reduced in the poloxamer 407-induced hyperlipidemic control rats. However, oral administration of both the MeOH extract and 4 fractions significantly increased HDL-C levels. Of the tested fractions, the EtOAc fraction showed the strongest lipid-lowering effect, as well as a high antiatherogenic potential with atherogenic index (A. I.) values of less than 1.92. We also investigated the hypolipidemic effects of the main compounds of the EtOAc fraction, kurarinol and kuraridinol, using the hyperlipidemic and hypercholesterolemic animal models. Here, elevated TC, TG, and LDL-C levels in the poloxamer 407-induced hyperlipidemic and cholesterol-fed rats were significantly reduced after oral administration of the compounds, and HDL-C levels had a significant increase. Furthermore, A.I. values were lowered by administering kurarinol and kuraridinol. In particular, kuraridinol exhibited stronger protective activities against hyperlipidemia than kurarinol. These results suggest that S. flavescens and its constituents may be effective cholesterol-lowering agents and useful for preventing hypercholesterolemic atherosclerosis.

• 社団法人日本薬学会の論文
• 2008-01-01

著者

• Yokozawa Takako

  Institute of Natural Medicine, University of Toyama

• Kim Hyun

  College Of Pharmacy Kangwon National University

• Yokozawa Takako

  Inst. Of Natural Medicine Univ. Of Toyama

• Yoshikawa T

  Institute Of Natural Medicine University Of Toyama

• JEONG Da

  Faculty of Food Science and Biotechnology, Pukyong National University

• JUNG Hee

  Faculty of Food Science and Biotechnology, Pukyong National University

• JUNG Yu

  Faculty of Food Science and Biotechnology, Pukyong National University

• CHOI Jae

  Faculty of Food Science and Biotechnology, Pukyong National University

• Kim Hyun

  Dep. Of Food Sci. Jinju National Univ.

• Yokozawa Takako

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Jung Yu

  Faculty Of Food Science And Biotechnology Pukyong National University

• Jeong Da

  Faculty Of Food Science And Biotechnology Pukyong National University

• Choi J

  Pukyong National Univ. Busan Kor

• Choi Jae

  Faculty Of Food Science And Biotechnology Pukyong National University

• Kim Hyun

  Univ. Toyama Toyama Jpn

• 横澤 隆子

  Inst. Of Natural Medicine Univ. Of Toyama

• Kim H

  Univ. Toyama Toyama Jpn

• Kim Hyun

  College Of Pharmacy And Research Institute Of Drug Development Chonnam National University

• Jung Hee

  Faculty Of Food Science And Biotechnology Pukyong National University

• Kim Hyun

  College Of Electrical & Computer Engineering Chungbuk National University

• Jung Yu

  Div. Of Food Sci. And Biotechnology Pukyong National Univ.

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