Triterpenoid Saponins of Pulsatilla koreana Root Have Inhibition Effects of Tumor Necrosis Factor-α Secretion in Lipopolysaccharide-Induced RAW264.7 Cells
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概要
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In the present study, a new oleanane-type triterpenoid saponin, pulsatilloside F (1), along with 21 known compounds (2–22), were isolated from the root of Pulsatilla koreana. Their chemical structures were elucidated by mass, 1H-, 13C-NMR, correlation spectroscopy (COSY), heteronuclear multiple quantum coherence (HMQC) and heteronuclear multiple bond connectivity (HMBC) spectroscopy. Anti-inflammatory effects of the compounds were evaluated in terms of inhibitory of tumor necrosis factor α (TNF-α) secretion in the lipopolysaccharide (LPS)-stimulated murine RAW264.7 macrophage cell line. Compounds 19 and 20 exhibited particularly inhibitory effects with respective IC50 values of 0.32 and 0.65 µ<span style="font-variant: small-caps;">m</span>. Compounds 1–4, 7 and 10–13 exhibited inhibitory effects with inhibition rates up to 41.55–73.76% at a concentration of 5 µ<span style="font-variant: small-caps;">m</span>, respectively.
著者
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Ding Yan
College of Pharmacy, Chungnam National University
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Yang Seo
College of Pharmacy, Chungnam National University
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Cha Ji
Department of Statistics, Ewha Womans University
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Lee Young
Department Of Aerospace Information Engineering The Konkuk University
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LEE Young
Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University
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Kim Young
Colledge of Pharmacy, Wonkwang University
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Li Wei
College of Materials Science and Engineering, Sichuan University, Chengdu 610064, China
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Sun Ya
College of Pharmacy, Chungnam National University
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Yan Xi
College of Pharmacy, Chungnam National University
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Choi Chun
College of Pharmacy, Chungnam National University
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Cha Ji
Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University
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