Effectiveness of Probucol in Preventing Restenosis after Percutaneous Transluminal Coronary Angioplasty.
スポンサーリンク
概要
- 論文の詳細を見る
Lipid lowering therapies were employed to prevent restenosis following elective percutaneous transluminal coronary angioplasty (PTCA). The effect of probucol was compared to that of Pravastatin in 141 coronary atherosclerosis patients. Probucol (750mg/day) was administered for at least 30 days prior to PTCA (34 patients, group P-1) or less than 14 days prior to PTCA (27 patients, group P-2). Pravastatin (10mg/day) was administered for at least 30 days prior to PTCA (38 patients, group V-1) or less than 14 days prior to PTCA (42 patients, group V-2). In group P-1, the patient restenosis rate was 17.6% and lesion restenosis rate was 14%. These rates were significantly lower than those of group V-1, which were 44.7% and 40.4% respectively (p<0.05). The respective values were 48.1% and 51.8% in group P-2 (p<0.05, vs group P-1) and 35.7% and 34% (p<0.05, vs group P-1) in group V-2. Probucol seems to work, not only by lowering cholesterol but also by its antioxidative properties when administered for a sufficient period prior to PTCA.
- International Heart Journal刊行会の論文
著者
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Yokoi Hisashi
Department Of Cardiology Juntendo University School Of Medicin
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Mokuno Hiroshi
Department Of Cardiovascular Medicine Juntendo University School Of Medicine
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Daida Hiroyuki
Department Of Cardiology
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Lee Young
Department Of Aerospace Information Engineering The Konkuk University
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Takaya Junshi
Department Of Cardiology Juntendo University School Of Medicine Tokyo And Juntendo Urayasu Hospital
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Miyano Hiroshi
Department Of Cardiology Koshigaya Municipal Hospital
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Yamaguchi Hiroshi
Department Of Anatomic Pathology Graduate School Of Medical Sciences Kyushu University
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Sakurai Hidehiko
Department Of Cardiology Jnutendo University School Of Medicine
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YOKOI Hisashi
Department of Cardiology, Juntendo University, School of Medicine
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TAKAYA Junshi
Department of Cardiology, Juntendo University, School of Medicine
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SAKURAI Hidehiko
Department of Cardiology, Juntendo University, School of Medicine
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Mokuno Hiroshi
Department of Cardiology, Juntendo University
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LEE Young
Department of Cardiology, Juntendo University, School of Medicine
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