Relationship between Plasma Homocysteine Levels and Saphenous Vein Graft Disease after Coronary Artery Bypass Grafts.
スポンサーリンク
概要
- 論文の詳細を見る
The long-term efficacy of coronary artery bypass graft (CABG) surgery is limited by saphenous vein graft (SVG) disease. Elevated levels of plasma homocysteine are a known independent risk factor for cardiovascular disease. However, its influence on the patency of SVG is unknown. To determine whether plasma homocysteine levels are related to SVG disease after CABG we measured homocysteine levels in 80 patients who underwent CABG (age: 64±8, interval after bypass surgery: 6.4±3.1, range: 1-13 years). The patients were divided into a vein graft disease group (more than 50% angiographical stenosis in any vein graft, n=40) and a no-vein graft disease group (<50% stenosis in any vein graft, n=40). The presence of a mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene was also determined by polymerase chain reaction. Homocysteine levels in the vein graft disease group were significantly higher than in the no-vein graft disease group (11.2 vs. 9.1 μmol/l, p=0.01). Multiple regression analysis showed that the interval after CABG was an independent factor for SVG disease (odds ratio: 1.014, 95% confidence intervals: 1.003-1.025, p=0.013) and elevated levels of homocysteine tended to be an independent factor for SVG disease (odds ratio: 1.098, 95% confidence intervals: 0.994-1.213, p=0.067). There was no significant difference in MTHFR genotypes between the two groups. These findings indicate that elevated levels of plasma homocysteine are related to SVG disease after CABG.
- International Heart Journal刊行会の論文
著者
-
Watanabe Yoshiro
Department of Cardiology, Juntendo University, School of Medicine
-
Yokoi Hisashi
Department Of Cardiology Juntendo University School Of Medicin
-
Iwama Yoshitaka
Department Of Cardiology
-
Hosoda Yasuyuki
Department Of Cardiothoracic Surgery Juntendo University School Of Medicine
-
Daida Hiroyuki
Department Of Cardiology
-
Watanabe Yoshiro
Department Of Cardiology Juntendo University School Of Medicine
-
Yamaguchi Hiroshi
Juntendo University School Of Medicine
-
SHIMADA Kazunori
Department of Biochemistry, Kumamoto University Medical School
-
MOKUNO Hiroshi
Department of Cardiology, Juntendo University, School of Medicine
-
Hosoda Yasuyuki
Department of Cardiovascular Surgery, Juntendo University, School of Medicine
-
Mokuno Hiroshi
Department of Cardiology, Juntendo University
-
Iwama Yoshitaka
Department of Cardiology, Juntendo University, school of Medicine
関連論文
- Clinical Characteristics of Defecation Syncope Compared With Micturition Syncope
- Prevalence of the Brugada-Type Electrocardiogram and Incidence of Brugada Syndrome in Patients With Sick Sinus Syndrome
- Age-Dependent Clinical Characteristics of Micturition Syncope
- Long-Term Clinical and Angiographic Follow-up in Patients With Isolated Ostial Stenosis of the Left Coronary Artery
- PJ-675 Deletion of Fc Receptor Reduces Atherosclerotic Lesions in LDL Receptor Knockout Mice : Role of Protection against Inflammation and Oxidative Stress(PJ113,Atherosclerosis, Basic 2 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting o
- 2 GATA3 is Essential for Tie2 Expression and its signaling in Endothelium(Young Investigator's Award for International Students Finalists Lecture (YIA International),Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
- DPE-063 Prognostic Value of Urinary Liver-type Fatty Acid-Binding Protein (L-FABP) in Patients with Acute Coronary Syndrome(DPE11,Kidney/Renal Circulation/CKD (H),Digital Poster Session (English),The 73rd Annual Scientific Meeting of The Japanese Circulat
- PJ-754 Intravascular Ultrasound Analysis of Coronary Atheroma in Patients with and without Chronic Kidney Disease following Statin Therapy from JAPAN-ACS Study(PJ127,Intravascular Imagings 2 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting
- Diabetes Mellitus Is a Major Negative Determinant of Coronary Plaque Regression During Statin Therapy in Patients With Acute Coronary Syndrome : Serial Intravascular Ultrasound Observations From the Japan Assessment of Pitavastatin and Atorvastatin in Acu
- Changes of Matrix Metalloproteinase-9 Level Is Associated With Left Ventricular Remodeling Following Acute Myocardial Infarction Among Patients Treated With Trandolapril, Valsartan or Both
- Diabetes Mellitus Is a Major Negative Determinant of Coronary Plaque Regression During Statin Therapy in Patients With Acute Coronary Syndrome : Serial Intravascular Ultrasound Observations From the Japan Assessment of Pitavastatin and Atorvastatin in Acu
- Rationale and Design of a Study to Examine Lower Targets for Low-Density Lipoprotein-Cholesterol and Blood Pressure in Coronary Artery Disease Patients : The Japanese Coronary Artery Disease Study II (JCADII)
- Clinical Significance of Intensive Lipid-Lowering Therapy Using Statins in Patients With Coronary Artery Disease : LDL-Cholesterol : The Lower, the Better ; Is It True for Asians? (Pro)
- OE-056 Non-HDL Cholesterol is Strong Predictor in Metabolic Syndrome for Long-Term Ten-Year Outcomes in Japanese Patients Undergoing CABG Surgery(Lipid disorders-1 (H) OE10,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the
- FRS-107 Early Pharmacological Intervention with Atorvastatin Regulates Th1/Th2 Imbalance in Patients with Acute Coronary Syndrome(Acute Coronary Syndrome (IHD) : FRS13)(Featured Research Session (English))
- Concentrations of Th1/Th2 Cytokines and C-Reactive Protein in Patients with Coronary Atherosclerosis and Acute Coronary Syndrome
- Circulating Oxidized Low-Density Lipoprotein Is an Independent Predictor for Cardiac Events in Patients with Coronary Artery Disease
- Ten-Year Follow-Up of Mortality in Patients Undergoing PCI and CABG
- Common polymorphism of CD14 monocyte receptor gene and concentrations of soluble CD14 in patients with restenosis after elective coronary stenting
- Randomized Trial of the Long-term Effects of Pravastatin on Coronary Artery Bypass Grafts : PCAB Study(Enrollment number : 60013)
- Potentially Protective Effects of the Ser447-Ter Mutation of the Lipoprotein Lipase Gene Against the Development of Coronary Artery Disease in Japanese Subjects Via a Beneficial Lipid Profile
- Association of Seropositivity for Antibody to Chlamydia-Specific Lipopolysaccharide and Coronary Artery Disease in Japanese Men
- Arrhythmogenic Right Ventricular Cardiomyopathy With an Initial Manifestation of Severe Left Ventricular Impairment and Normal Contraction of the Right Ventricle
- Local Delivery Infusion Pressure is a Key Determinant of Vascular Damage and Intimal Thickening
- 0815 Percutaneous Transluminal Coronary Angioplasty in Patients with Multivessel Coronary Disease : Dose Complete Revascularization Improve the Long Term Survival?
- 0331 The relation between HDL subclasses and coronary artery disease in individuals with a predominance of small LDL and low HDL cholesterolemia
- PJ-734 Impact of Chronic Kidney Disease on Severity of Coronary Artery Disease(PJ123,Kidney/Renal Circulation/CKD 6 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)
- PJ-040 The Impact of Chronic Kidney Disease on Long-term Outcome after Acute Coronary Syndrome, over a 10-Year Follow Up Period(PJ007,Kidney/Renal Circulation/CKD 1 (H),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulati
- PE-374 Propensity Analysis of Long-term Outcome (Total-mortality and Acute Coronary Syndrome) of Drug-Eluting Stents versus Bare-Metal Stents(PE063,Coronary Revascularization, PCI (DES) 5 (IHD),Poster Session (English),The 73rd Annual Scientific Meeting o
- PE-136 Effects of Calcium-channel Blocker and Angiotensin-Receptor Blocker on Endothelial Dysfunction and Inflammation Induced by Drug-Eluting Stent(PE023,Coronary Revascularization, PCI (DES) 3 (IHD),Poster Session (English),The 73rd Annual Scientific Me
- DPJ-011 Chronic Kidney Disease Predicts Long-term Mortality after Coronary Artery Bypass Surgery in Patients with and without Metabolic Syndrome(DPJ02,Cardiovascular Surgery/CABG (IHD),Digital Poster Session (Japanese),The 73rd Annual Scientific Meeting o
- OJ-223 Propensity Analysis of Long-term Outcome of Coronary Artery Bypass Graft versus Balloon Angioplasty in Patients with Chronic Kidney Disease(OJ38,Atherosclerosis (Clinical/Treatment) (IHD),Oral Presentation (Japanese),The 73rd Annual Scientific Meet
- OJ-182 Long-term Outcome after an Early Statin Treatment in Patients with Acute Coronary Syndrome (Extended-ESTABLISH trial) : A Long-Term Follow up Results(OJ31,ACS/AMI (Clinical/Treatment) (IHD),Oral Presentation (Japanese),The 73rd Annual Scientific Me
- OJ-162 Clinical Implication of Measurement of Serum NT-ProBNP Level in Patients with Coronary Artery Disease(OJ27,Coronary Circulation/Chronic Coronary Disease (Basic/Clinical) (IHD),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The J
- OJ-026 Differences in Vascular Response and Renal Function following Moderate or Aggressive Lipid Lowering Therapy in Hypercholesterolemic Patients with Cardiovascular Diseases(OJ05,Peripheral Circulation/Vascular Disease (Therapy) 1 (H),Oral Presentation
- OE-361 Fasting Triglyceride Level is a Risk Factor for 10-years Long-Term Cardiac Death among Patients who Underwent Complete Coronary Revascularization(OE61,Lipid Disorders (H),Oral Presentation (English),The 73rd Annual Scientific Meeting of The Japanes
- OE-349 Beneficial Effect of Sirolimus-Eluting Stents versus Bare Metal Stents following Rotational Atherectomy on Long-term Cardiovascular Events(OE59,Coronary Revascularization, PCI (Complex Lesions) (IHD),Oral Presentation (English),The 73rd Annual Scie
- OE-166 Long-Term Outcomes of Sirolimus-Eluting Stent versus Off-pump Coronary Artery Bypass Grafting in Diabetics with Multivessel Coronary Disease Involving Proximal LAD(OE28,Coronary Revascularization, PCI (Restenosis/Others) 1 (IHD),Oral Presentation (
- FRS-088 Trends in Long-Term Outcomes in Diabetes after Percutaneous Coronary Intervention : A 22-Year Long-term Follow-up in Single Center Registry(FRS18,New Insights into Metabolic Syndrome (H),Featured Research Session (English),The 73rd Annual Scientif
- FRS-057 Short-term Plaque Regression with Intravascular Ultrasound Predicts Long-term Outcomes in Patients with Acute Coronary Syndrome(FRS12,New Approaches to Atherosclerosis Research (IHD),Featured Research Session (English),The 73rd Annual Scientific M
- Metabolic Syndrome Predicts 10-Year Mortality in Non-Diabetic Patients Following Coronary Artery Bypass Surgery
- Effects of Phase III Cardiac Rehabilitation on Mortality and Cardiovascular Events in Elderly Patients With Stable Coronary Artery Disease
- Effects of a Phase III Cardiac Rehabilitation Program on Physical Status and Lipid Profiles in Elderly Patients With Coronary Artery Disease : Juntendo Cardiac Rehabilitation Program (J-CARP)
- Insulin Response to Oral Glucose Load is Associated with Coronary Artery Disease in Subjects with Normal Glucose Tolerance
- PJ-630 Fc Receptor for Immunoglobulin May Play Functional Role in Endothelium-dependent Vascular Relaxation and Production of Superoxide in Hypercholesterolemic Mice(Atherosclerosis, basic-6 (H) PJ106,Poster Session (Japanese),The 70th Anniversary Annual
- PJ-389 Nuclear Magnetic Resonance Spectroscopy Reveals Atherogenic Dyslipoproteinemia in the Metabolic Syndrome(Lipid Disorders 2 (IHD) : PJ65)(Poster Session (Japanese))
- OJ-063 Plasma Oxidized Low-density Lipoprotein Is a Strong Predictor of Cardiac Events in Type 2 Diabetic Patients with Coronary Artery Disease(Lipid Disorders 1 (H) : OJ8)(Oral Presentation (Japanese))
- R/R Genotype of Human Paraoxonase (PON1) is More Protective against Lipoprotein Oxidation and Coronary Artery Disease in Japanese Subjects
- Effects of Phase III Cardiac Rehabilitation Programs on Health-Related Quality of Life in Elderly Patients With Coronary Artery Disease : Juntendo Cardiac Rehabilitation Program (J-CARP)
- ACE genotype predict the efficacy of cardiac rehabilitation on QOL of elderly patients with CHD : Juntendo Cardiac Rehabilitation Program (J-CARP)
- Trends of Coronary Atherosclerosis and its Coronary Risk Factors in Japanese Patients with Valvular Regurgitation
- Troglitazone Improves Endothelial Dysfunction in Patients with Insulin Resistance
- High Level of Lipoprotein(a) is a Strong Predictor for Progression of Coronary Artery Disease
- ASSOCIATION OF LDL SUBCLASS AND CORONARY RISK FACTORS WITH ANGIOGRAPHICALLY DEFINED CORONARY ARTERY DISEASE (CAD)
- Venous Coronary Artery Bypass Grafting : Late Results of a 15-Year Actuarial Follow-Up in 486 Patients
- Aortic and Mitral Valve Replacement in a Patient with Acute Febrile Neutrophilic Dermatosis (Sweet's Syndrome) : Report of a Case
- Left Antero-Axillary Thoracotomy as an Alternative Approach for Aortic Arch Reconstruction
- Coronary Artery Bypass Grafting : Late Result of Actual 10-Years Follow-up in 376 Patients
- -1274-INTERRELATION BETWEEN DYNAMIC STIFFNESS AND ELASTANCE IN THE EJECTING CANINE HEART : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -106-EFFECTS OF PACING TACHYCARDIA AND ISOSORBIDE DINITERATE IN ISCHEMIC HEART DISEASE ON CARDIAC WORK EFFICIENCY EVALUATED WITH VOLUMIC CONDUCTANCE CATHETER : Ventricular Function : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETI
- Comparison of Aggressive Strategy of Immediate Coronary Stenting after Thrombolysis with Primary Stenting for Acute Myocardial Infarction
- -0095-LONG-TERM PROGNOSIS AFTER CORONARY ARTERY BYPASS SURGERY AND RISK FACTORS AFFECTING LONG-TERM PATENCY OF SAPHENOUS VEIN GRAFTS
- OE-248 Serum Uric Acid as a Prognostic Predictor in Pulmonary Arterial Hypertension with Collagen Disease(Pulmonary circulation-1 (H) OE42,Oral Presentation (English),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)
- 5 Current Status and Future Perspectives of Diastolic Heart Failure in Japan : Possible Importance of Metabolic Syndrome(Pathophysiology and Therapeutic Strategy of Diastolic Dysfunction in Heart Failure,Plenary Session 4 (PL-4) (IHD),The 73rd Annual Scie
- OE-239 Elevation of C-reactive protein is associated with sleep-disordered breathing in patients with congestive heart failure(Heart Failure, Clinical 9 (M) : OE30)(Oral Presentation (English))
- Transgenic rat models of vasopressin overexpression
- Elevated Levels of Plasma Total Homocysteine are Associated with Coronary Event in Patients with Metabolic Syndrome(Metabolism/Biochemistry/Energetics 1 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- A Case of Primary Glucocorticoid Resistance
- Coronary Artery and Graft Spasm after Off-pump Coronary Artery Bypass Grafting
- Surgical Treatment for Primary Cardiac Leiomyosarcoma Causing Right Ventricular Outflow Obstruction
- A Japanese Case of Familial Cardiac Myxoma Associated with a Mutation of the PRKAR1α Gene
- Morphological Studies on Middle Ear Barotrauma in Guinea Pigs
- -1219- INTERNAL THORACIC ARTERY BYPASS : LONG-TERM CLINICAL OUTCOME ANALYSIS OF DETERMINANTS AFFECTING LATE SURVIVAL(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- -1216- OPERATIVE OUTCOME AND LONG TERM SURVIVAL OF PTCA AND CABG IN PATIENTS OVER 70 YEARS OLD(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY)
- INTRAVASCULAR ULTRASOUND IMAGING OF ANGIOGRAPHICALLY NORMAL OR MILDLY DISEASED LEFT MAIN CORONARY ARTERIES
- -164-EFFECTS OF SERUM LIPID PROFILE ON RESTENOSIS AFTER PTCA : Arteriosclerosis : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Relationship between Thromboembolic Complications and the Intensity of Anticoagulation in Patients with Aortic Valve Replacement
- Angiographic Assessment of the Stretch-Recoil-Gain Relation After Ballon Coarctation Angioplasty and Its Relation to Late Restenosis
- Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells
- Estimated glomerular filtration rate is an independent predictor for mortality of patients with acute heart failure
- String-Sign in Left Internal Thoracic Artery Is Associated With Regression in Left Main Trunk Stenosis After Coronary Artery Bypass
- Changes in Serum Myosin Light Chain I Following Aortocoronary Bypass Operations
- 経食道心エコー法 (TEE) により診断された四尖弁大動脈弁症例報告
- Cerebral Vein Disorders and Postoperative Brain Damage Associated with the Pterional Approach in Aneurysm Surgery
- Endoscopic Monitoring of Operative Procedures During Cardiac Surgery
- Retrograde Cerebral Perfusion Exceeding 120 Minutes in Aortic Arch Reconstruction:A Report of Two Cases
- Ascending Aorta to Supraceliac Abdominal Aorta Bypass for Coarctation of the Aorta in an Adult
- A New Technique for Performing Mitral Valve Repair in a Small Left Atrium
- Fibrin Glue and Bioabsorbable Felt Patch for Intraoperative Intractable Air Leaks
- Drug concentration in lymph nodes after preoperative administration of UFT (a blend of Tegafur and uracil) for non-small-cell lung cancer
- 17. Report of a Case of Unilateral Intention Tremor as a Complication of Bilateral Posterior Sub-C.M.Thalamotomy for Intractable Pain
- Prevalence and Clinical Implication of Metabolic Syndrome in Chronic Heart Failure : Report From MetS-CHF Study
- -225-THE VALUE OF AORTO-CORONARY BYPASS GRAFT FLOW MEASUREMENT
- Papillary Fibroelastoma of the Tricuspid Valve in Association with an Atrial Septal Defect : Report of a Case
- GATA3 abnormalities in six patients with HDR syndrome
- Association of Serum Antioxidant Capacity with Coronary Artery Disease in Middle-aged Men
- Serum Uric Acid as a Prognostic Predictor in Pulmonary Arterial Hypertension With Connective Tissue Disease
- Coronary Artery Bypass Grafting with Cardiopulmonary Bypass is Safe and Contributes to Favorable Long-term Results.
- Relationship between Plasma Homocysteine Levels and Saphenous Vein Graft Disease after Coronary Artery Bypass Grafts.
- Effectiveness of Probucol in Preventing Restenosis after Percutaneous Transluminal Coronary Angioplasty.