Conversion and Maintenance of Sinus Rhythm by Bepridil in Patients With Persistent Atrial Fibrillation
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概要
- 論文の詳細を見る
Background Bepridil has multiple ion-channel blocking effects similar to armodarone and is expected to have anti-arrhythmic effects that are useful for the management of atrial fibrillation (AF). The aim of this study was to clarify the conversion of persistent AF and maintenance of sinus rhythm (SR) by oral bepridil. Methods and Results Oral bepridil was administered to 112 patients (83 males, 29 females; age: 59.0±10.8 years) with persistent AF lasting an average of 5 months. The conversion effects and maintenance of SR after pharmacological or direct current (DC) cardioversion, as well as the incidence of adverse complications, were evaluated. In 65 of 112 (58%) patients, SR was restored within 6 months (average: 2.1 months) following bepridil administration. DC cardioversion was carried out for 21 of the remaining 47 patients with unsuccessful pharmacological conversion, and all had restoration of SR. Eventually, of the 86 patients in total who were restored to SR by either bepridil or DC cardioversion, 70 (81%) patients maintained SR after a mean follow-up of 18 months. No serious adverse complications were observed, except for marked QT prolongation in 2 cases. Conclusion Bepridil showed favorable conversion effects in patients with persistent AF and was highly effective for maintaining SR after pharmacological or electrical cardioversion. However, careful follow-up is necessary for the prevention of torsade de pointes caused by QT prolongation.
- 社団法人日本循環器学会の論文
- 2004-12-20
著者
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TOKANO Takashi
Department of Cardiology, Juntendo University Shizuoka Hospital
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NAKAZATO Yuji
Department of Cardiology, Juntendo University Urayasu Hospital
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DAIDA Hiroyuki
Department of Cardiology, Juntendo University School of Medicine
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YASUDA Masayuki
Department of Cardiology, Juntendo University School of Medicine
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KAWANO Yasunobu
Department of Cardiology, Juntendo University Urayasu Hospital
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Nakazato Kaoru
Department of Cardiovascular Medicine, Juntendo University School of Medicine
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Tokano Takashi
Department Of Cardiology Juntendo University Shizuoka Hospital
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Sumiyoshi Masataka
Department Of Cardiology Juntendo University Nerima Hospital
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Nakata Yasuro
Department Of Cardiology Juntendo University Urayasu Hospital
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Nakazato Yuji
Cardiovascular Medicine Juntendo University Urayasu Hospital
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Mineda Yoriaki
Department Of Cardiology Juntendo University Shizuoka Hospital
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Sasaki Akitoshi
Department of Cardiology, Juntendo University School of Medicine
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Sumiyoshi Masataka
Juntendo Shizuoka Hospital
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Iida Youji
Department of Cardiology, Juntendo University School of Medicine
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Mineda Yoriaki
Juntendo Izu-Nagaoka Hospital
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Nakata Yasuro
Juntendo Izu-Nagaoka Hospital
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Sasaki Akitoshi
Department Of Cardiology Juntendo University School Of Medicine
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Iida Youji
Department Of Cardiology Juntendo University School Of Medicine
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Yasuda Masayuki
Department Of Cardiology Juntendo University School Of Medicine
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Nakata Yasuro
Cardiology Dept. Of Internal Medicine Juntendo University
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Kawano Yasunobu
Department Of Cardiology Juntendo University Urayasu Hospital
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Daida Hiroyuki
Department Of Cardiology
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Nakazato Yuji
Department Of Cardiology Heart Center Juntendo University Urayasu Hospital
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Nakazato Kaoru
Department Of Cardiology Juntendo University School Of Medicine
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Nakata Yasuro
Division Of Cardiology Department Of Internal Medicine School Of Medicine Juntendo University
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