Steamed Ginseng-Leaf Components Enhance Cytotoxic Effects on Human Leukemia HL-60 Cells
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概要
- 論文の詳細を見る
Three new dammarane-type glycosides, named ginsenosides SL1—SL3 (1—3), and eleven known compounds (4—14) were isolated from the heat-processed leaves of Panax ginseng. Their structures were elucidated on the basis of extensive chemical and spectroscopic methods. Cytotoxic-activity testing of compounds 1—14 against human leukemia HL-60 cells showed that ginsenosides Rh3 (11) and Rk2 (12) exhibited potent effects with IC50 values of 0.8 and 0.9 μM. In addition, ginsenosides SL3 (3), 20S-Rg2 (7), F4 (10), 20S-Rh2 (13) displayed strong activity with IC50 values of 9.0, 9.0, 7.5, and 8.2 μM, respectively. This is the first report on chemical components of the steamed ginseng leaves.
著者
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Kim Young
College of Pharmacy, Chungnam National University
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TUNG Nguyen
College of Pharmacy, Chungnam National University
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MINH Chau
Institute of Natural Products Chemistry, Vietnamene Academy of Science and Technology
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Song Gyu
College of Pharmacy, Chungnam National University
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Kiem Phan
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology
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Jin Long
College of Pharmacy, Chungnam National University
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Boo Hye-Jin
Department of Pharmacology, School of Medicine, Institute of Medical Sciences, Jeju National Univers
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Kang Hee-Kyoung
Department of Pharmacology, School of Medicine, Institute of Medical Sciences, Jeju National Univers
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Song Gyu
College Of Pharmacy Chungnam National University
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Kang Hee-kyoung
Department Of Pharmacology College Of Medicine Cheju National University
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Kim Young
College Of Pharmacy And Research Institute Of Pharmaceutical Science Seoul National University
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Kim Young
Colledge of Pharmacy, Wonkwang University
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Kiem Phan
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology
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Minh Chau
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology
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Minh Chau
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology
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Boo Hye-Jin
Department of Pharmacology, School of Medicine, Institute of Medical Sciences, Jeju National University
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Kang Hee-Kyoung
Department of Pharmacology, School of Medicine, Institute of Medical Sciences, Jeju National University
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