Hepatoprotective Dibenzylbutyrolactone Lignans of Torreya nucifera against CCl_4-Induced Toxicity in Primary Cultured Rat Hepatocytes(Pharmacognosy)
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概要
- 論文の詳細を見る
Three dibenzylbutyrolactone lignans, (-)-arctigenin, (-)-traxillagenin, and (-)-4'-demethyltraxillagenin, isolated from the bark of Torreya nucifera SIEB. et ZUCC. (Taxaceae) showed significant hepatoprotective activity in primary cultures of rat hepatocytes injured by carbon tetrachloride (CCl_4). These lignans reduced the release of glutamic pyruvic transaminase into the culture medium from the CCl_4-injured primary cultures of rat hepatocytes. Further investigation revealed that the three lignans significantly preserved the level of glutathione (GSH) and activities of superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase in the CCl_4-injured rat hepatocytes. The lignans also ameliorated lipid peroxidation as demonstrated by a reduction in malondialdehyde-related products. Moreover, these lignans significantly attenuated the GSH reduction caused by diethylmaleate which depletes GSH through the formation of stable conjugates. However, these lignans showed no effect on the GSH synthesis inhibited by buthionine sulfoximine. From these results, it can be concluded that arctigenin, traxillagenin, and 4'-demethyltraxillagenin may protect hepatocytes from CCl_4 injury by maintaining the GSH level.
- 公益社団法人日本薬学会の論文
- 2003-08-01
著者
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Kim Young
College of Pharmacy, Chungnam National University
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Sung Sang
College of Pharmacy, Seoul National University
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Kim Seung
College of Bioscience and Biotechnology, Department of Biomaterials Engineering, Kangwon National Un
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Kim Yun
Colledge Of Pharmacy Wonkwang University
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Kim Youn
韓国
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Kim J
College Of Pharmacy Seoul National University
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Kim Chang
College Of Pharmacy Chung Ang University
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Kim Young
Department Of Physiology And Biophysics Seoul National University College Of Medicine
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Kim Jin
College of Oriental Medicine, Kyung Hee University
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Kim Young
College Of Pharmacy And Research Institute Of Pharmaceutical Science Seoul National University
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Kim S
National Institute Of Toxicological Research Korea Food And Drug Administration
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Kim Chang
College Of Agriculture Gyeongsang National University
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Sung S
Seoul National Univ. Seoul Kor
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JANG Young
College of Pharmacy, Seoul National University
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Kim Young
Coll. Of Pharmacy And Res. Inst. Of Pharmaceutical Sci. Seoul National Univ.
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Kim Y
Coll. Of Pharmacy And Res. Inst. Of Pharmaceutical Sci. Seoul National Univ.
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Sung Sang
College Of Pharmacy Seoul National University
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Jang Young
College Of Pharmacy Seoul National University
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Sung Sang
College Of Pharmacy And Research Institute Of Pharmaceutical Science Seoul National University
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Kim Chang
College Of Advanced Technology Kyung Hee University
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Kim Young
Colledge of Pharmacy, Wonkwang University
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