Effects of Dimethylsulfoxide on Metabolism and Toxicity of Acetaminophen in Mice(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
Effects of dimethylsulfoxide (DMSO) on metabolism and toxicity of acetaminophen (APAP) were examined using male mice. A dose of DMSO (1ml/kg, i.p.) inhibited the induction of APAP hepatotoxicity almost completely as indicated by changes in serum hepatotoxic parameters. Quantification of major APAP metabolites in plasma showed that APAP-glutathione (GSH), a conjugate generated via metabolic activation of APAP, was reduced significantly while APAP-sulfate and APAP-glucuronide, detoxified metabolites both produced directly from the parent drug, were increased in mice pretreated with DMSO. However, microsomal CYP2E1 activity measured with p-nitrophenol and p-nitroanisole as substrates was increased by DMSO treatment. Generation of APAP-GSH in microsomes from control mice was inhibited by DMSO in a dose-dependent manner. Lineweaver-Burk plot analysis indicated that the inhibition pattern produced by DMSO was competitive in nature. A 10000g supernatant was reconstituted with the cytosolic fraction and microsomes from DMSO- or saline-treated animals. APAP-GSH production was increased significantly when the cytosolic fraction from saline-treated mice and/or microsomes from DMSO-treated mice were used. The results indicate that DMSO induces the enzyme activity responsible for oxidative metabolism of APAP, but its direct inhibitory effect on the enzymatic interaction with this drug decreases the overall production of a reactive metabolite, resulting in reduction of the hepatotoxicity. It is suggested that DMSO effects on metabolism of a xenobiotic would vary depending on its potential to inhibit the interaction of enzyme (s) and the xenobiotic.
- 公益社団法人日本薬学会の論文
- 2006-08-01
著者
-
Kim Young
College of Pharmacy, Chungnam National University
-
Kim Sun
College Of Pharmacy Seoul National University
-
LEE Byung-Hoon
College of Pharmacy, Wonkwang University
-
YOON Mi
College of Pharmacy, Seoul National University
-
CHUNG Jin-Ho
College of Pharmacy, Seoul National University
-
Lee Byung-hoon
College Of Pharmacy And Research Institute Of Pharmaceutical Sciences Seoul National University
-
Kim Young
College Of Pharmacy And Research Institute Of Pharmaceutical Science Seoul National University
-
Chung Jin-ho
College Of Pharmacy Seoul National University
-
Yoon Mi
College Of Pharmacy Seoul National University
-
Kim Sun
College Of Medicine Korea University
-
Kim Young
College Of Pharmacy Seoul National University:research Institute Of Pharmaceutical Sciences Seoul Na
-
Lee Byung-hoon
College Of Pharmacy Seoul National University
-
Kim Young
Colledge of Pharmacy, Wonkwang University
関連論文
- Steamed Ginseng-Leaf Components Enhance Cytotoxic Effects on Human Leukemia HL-60 Cells
- Phenolic Compounds from Artemisia iwayomogi and Their Effects on Osteoblastic MC3T3-E1 Cells
- Oral Administration of Curcumin Suppresses Production of Matrix Metalloproteinase (MMP)-1 and MMP-3 to Ameliorate Collagen-Induced Arthritis : Inhibition of the PKCδ/JNK/c-Jun Pathway
- Lipid production in Porphyridium cruentum grown under different culture conditions(BIOCHEMICAL ENGINEERING)
- Enhanced Solubility and Bioavailability of Sibutramine Base by Solid Dispersion System with Aqueous Medium
- New Neolignan Component from Camellia amplexicaulis and Effects on Osteoblast Differentiation
- Defects study of retrograde twin well CMOS that has MeV ion implanted buried layer
- Defects study of retrograde twin well CMOS that has MeV ion implanted buried layer
- New Triterpenoid Saponins from Glochidion eriocarpum and Their Cytotoxic Activity
- Chemical Constituents from the Leaves of Manglietia phuthoensis and Their Effects on Osteoblastic MC3T3-E1 Cells
- New Cembranoid Diterpenes from the Vietnamese Soft Coral Sarcophyton mililatensis Stimulate Osteoblastic Differentiation in MC3T3-E1 Cells
- Caesaldecan, a Cassane Diterpenoid from the Leaves of Caesalpinia decapetala
- Lupane-triterpene Carboxylic Acids from the Leaves of Acanthopanax trifoliatus
- Quinolone Alkaloids with Inhibitory Activity against Nuclear Factor of Activated T Cells from the Fruits of Evodia rutaecarpa(Pharmacognosy)
- Zeaxanthin Dipalmitate from Lycium chinense Fruit Reduces Experimentally Induced Hepatic Fibrosis in Rats
- A Novel Cerebroside from Lycii Fructus Preserves the Hepatic Glutathione Redox System in Primary Cultures of Rat Hepatocytes
- A New Monoterpenoid Glycoside from Myrica esculenta and the Inhibition of Angiotensin I-Converting Enzyme
- α-Glucosidase Inhibition Properties of Cucurbitane-Type Triterpene Glycosides from the Fruits of Momordica charantia
- N-Nitrosocarbofuran Induces Apoptosis in Mouse Brain Microvascular Endothelial Cells (bEnd.3)
- Lupane Triterpene Glycosides from Leave of Acanthopanax koreanum and Their Cytotoxic Activity
- Magnolia officinalis Reverses Alcoholic Fatty Liver by Inhibiting the Maturation of Sterol Regulatory Element-Binding Protein-1c
- Phenylplropene A and B, New Inhibitors of Acyl-CoA : Cholesterol Acyltransferase Produced by Penicillium griseofulvum F1959
- Effects of Dimethylsulfoxide on Metabolism and Toxicity of Acetaminophen in Mice(Pharmacology)
- Sauchinone, a Lignan from Saururus chinensis, Attenuates CCl_4-Induced Toxicity in Primary Cultures of Rat Hepatocytes
- Inhibitory Effects of Ethaverine, a Homologue of Papaverine, on Monoamine Oxidase Activity in Mouse Brain
- (+)-α-Viniferin, a Stilbene Trimer from Caragana chamlague, Inhibits Acetylcholinesterase
- Two New Dammarane-Type Saponins from the Leaves of Panax ginseng
- Enhancement of Menadione-Induced Cytotoxicity to Platelets by the Presence of Blood Plasma
- Cytotoxic Alkaloids and a Flavan from the Bulbs of Crinum asiaticum var.japonicum
- Two New Neolignans from the Aerial Parts of Rodgersia podophylla
- Two New Acylated Iridoid Glucosides from the Aerial Parts of Paederia scandens
- Inhibitory Effect of TNF-α and IL-8 Secretion by Pimarane-Type Diterpenoids from Acanthopanax koreanum
- Alteration in Metabolism and Toxicity of Acetaminophen Upon Repeated Administration in Rats
- Hepatoprotective Dibenzylbutyrolactone Lignans of Torreya nucifera against CCl_4-Induced Toxicity in Primary Cultured Rat Hepatocytes(Pharmacognosy)
- Sauchinone, a Lignan from Saururus chinensis, Inhibits Staurosporine-Induced Apoptosis in C6 Rat Glioma Cells(Pharmacognosy)
- Expression of Thrombogenic Activity by Lysophosphatidic Acid in Human Erythrocytes
- Gymnasterkoreayne G, a New Inhibitory Polyacetylene against NFAT Transcription Factor from Gymnaster koraiensis
- New Inhibitor against Nuclear Factor of Activated T Cells Transcription from Ribes fasciculatum var. chinense
- Oleanane Triterpenoids with Inhibitory Activity against NFAT Transcription Factor from Liquidambar formosana (Pharmacognosy)
- FORMATION OF 8-OXODEOXYGUANOSINE IN LIVER DNA AND HEPATIC INJURY BY PEROXISOME PROLIFERATOR CLOFIBRATE AND PERFLUORODECANOIC ACID IN RATS
- 44-Homooligomycilm E, a New Cytotoxic Macrolide Antibiotic from Streptomyces ostreogriseus
- 41-Demethylhomooligomycin B, a New Immunosuppresant Antibiotic from Streptomyces ostreogriseus
- Aclacinomycin X, a Novel Anthracycline Antibiotic Produced by Streptomyces galilaeus ATCC 31133
- Anti-inflammatory Activity of the Synthetic Chalcone Derivatives : Inhibition of Inducible Nitric Oxide Synthase-Catalyzed Nitric Oxide Production from Lipopolysaccharide-Treated RAW 264.7 Cells(Pharmacology)
- Crinamine from Crinum asiaticum var. japonicum Inhibits Hypoxia Inducible Factor-1 Activity But Not Activity of Hypoxia Inducible Factor-2(Pharmacognosy)
- New Pyrano-Pyrone from Goniothalamus tamirensis Enhances the Proliferation and Differentiation of Osteoblastic MC3T3-E1 Cells
- A New Neuroprotective Pinusolide Derivative from the Leaves of Biota orientalis
- New Tetrahydrofuran-Type Sesquilignans of Saurus chinensis Root
- Effect of Dimethyl-4,4'-dimethoxy-5,6,5', 6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate (DDB) on Chemical-Induced Liver Injury
- Rhapontigenin Inhibited Hypoxia Inducible Factor 1 Alpha Accumulation and Angiogenesis in Hypoxic PC-3 Prostate Cancer Cells
- Effect of Taurine on Biliary Excretion and Metabolism of Acetaminophen in Male Hamsters(Toxicology)
- Stimulatory Activity of Lignans from Machilus thunbergii on Osteoblast Differentiation(Pharmacognosy)
- Effect of Neuroprotective Flavonoids of Agrimonia eupatoria on Glutamate-Induced Oxidative Injury to HT22 Hippocampal Cells
- Acteoside of Callicarpa dichotoma Attenuates Scopolamine-Induced Memory Impairments(Pharmacology)
- Effects of Carbon Tetrachloride Pretreat-ment on Hepato- and Nephrotoxicity of Halogenated Hydrocarbons in Mice
- IS-96 The prognostic value of the serum FSH and estradiol level in IVF cycles treated with GnRH Agonist
- UDPGT cDNA EXPRESSION AND UDPGT1 IN HUMAN LIVER
- Total Peroxynitrite Scavenging Capacity of Phenylethanoid and Flavonoid Glycosides from the Flowers of Buddleja officinalis
- Oleanolic Triterpene Saponins from the Roots of Panax bipinnatifidus
- The antioxidant effects of Joongpoongtang 05 on brain injury after transient focal cerebral ischemia in rats
- Antifibrotic activity of coumarins from Cnidium monnieri fruits in HSC-T6 hepatic stellate cells
- In vitro validation of drug-induced phospholipidosis
- Proliferating effect of orotic acid through mTORC1 activation mediated by negative regulation of AMPK in SK-Hep1 hepatocellular carcinoma cells
- New non-quinone geldanamycin analogs from genetically engineered Streptomyces hygroscopicus
- Labdane-Type Diterpenoids from the Rhizomes of Hedychium coronarium Inhibit Lipopolysaccharide-Stimulated Production of Pro-inflammatory Cytokines in Bone Marrow-Derived Dendritic Cells
- (1S,2S,3E,7E,11E)-3,7,11,15-Cembratetraen-17,2-olide, a Cembrenolide Diterpene from Soft Coral Lobophytum sp., Inhibits Growth and Induces Apoptosis in Human Colon Cancer Cells through Reactive Oxygen Species Generation
- Plantagiolides I and J, Two New Withanolide Glucosides from Tacca plantaginea with Nuclear Factor-kappaB Inhibitory and Peroxisome Proliferator-Activated Receptor Transactivational Activities
- Diterpenoids from the Soft Coral Sinularia maxima and Their Inhibitory Effects on Lipopolysaccharide-Stimulated Production of Pro-inflammatory Cytokines in Bone Marrow-Derived Dendritic Cells
- Antifibrotic Activity of Diarylheptanoids from Betula platyphylla toward HSC-T6 Cells
- Triterpenoid Saponins of Pulsatilla koreana Root Have Inhibition Effects of Tumor Necrosis Factor-α Secretion in Lipopolysaccharide-Induced RAW264.7 Cells
- Quinone Derivatives from the Rhizomes of Acorus gramineus and Their Biological Activities