Alteration in Metabolism and Toxicity of Acetaminophen Upon Repeated Administration in Rats
スポンサーリンク
概要
- 論文の詳細を見る
Our previous studies showed that administration of a subtoxic dose of acetaminophen (APAP) to female rats increased generation of carbon monoxide from dichloromethane, a metabolic reaction catalyzed mainly by cytochrome P450 (CYP) 2E1. In this study we examined the changes in metabolism and toxicity of APAP upon repeated administration. An intraperitoneal dose of APAP (500 mg/kg) alone did not increase aspartate aminotransferase, alanine aminotransferase, or sorbitol dehydrogenase activity in serum, but was significantly hepatotoxic when the rats had been pretreated with an identical dose of APAP 18 h earlier. The concentrations and disappearance of APAP and its metabolites in plasma were monitored for 8 h after the treatment. APAP pretreatment reduced the elevation of APAP-sulfate, but increased APAP-cysteine concentrations in plasma. APAP or APAP-glucuronide concentrations were not altered. Administration of a single dose of APAP 18 h before sacrifice increased microsomal CYP activities measured with p-nitrophenol, p-nitroanisole, and aminopyrine as probes. Expression of CYP2E1, CYP3A, and CYP1A proteins in the liver was also elevated significantly. The results suggest that administration of APAP at a subtoxic dose may result in an induction of hepatic CYP enzymes, thereby altering metabolism and toxicological consequences of various chemical substances that are substrates for the same enzyme system.
- 2009-10-20
著者
-
Kim Young
College Of Pharmacy And Research Institute Of Pharmaceutical Science Seoul National University
-
Kim Sun
College Of Medicine Korea University
-
Kim Sung
College Of Pharmacy Seoul National University
-
Lee Min
College Of Pharmacy Chungbuk National University
-
Kwon Do
College Of Pharmacy Seoul National University
-
Lee Min
College Of Pharmacy Seoul National University
-
Kim Young
Colledge of Pharmacy, Wonkwang University
関連論文
- Steamed Ginseng-Leaf Components Enhance Cytotoxic Effects on Human Leukemia HL-60 Cells
- Phenolic Compounds from Artemisia iwayomogi and Their Effects on Osteoblastic MC3T3-E1 Cells
- Oral Administration of Curcumin Suppresses Production of Matrix Metalloproteinase (MMP)-1 and MMP-3 to Ameliorate Collagen-Induced Arthritis : Inhibition of the PKCδ/JNK/c-Jun Pathway
- Lipid production in Porphyridium cruentum grown under different culture conditions(BIOCHEMICAL ENGINEERING)
- Enhanced Solubility and Bioavailability of Sibutramine Base by Solid Dispersion System with Aqueous Medium
- New Neolignan Component from Camellia amplexicaulis and Effects on Osteoblast Differentiation
- New Triterpenoid Saponins from Glochidion eriocarpum and Their Cytotoxic Activity
- Chemical Constituents from the Leaves of Manglietia phuthoensis and Their Effects on Osteoblastic MC3T3-E1 Cells
- New Cembranoid Diterpenes from the Vietnamese Soft Coral Sarcophyton mililatensis Stimulate Osteoblastic Differentiation in MC3T3-E1 Cells
- Caesaldecan, a Cassane Diterpenoid from the Leaves of Caesalpinia decapetala
- Lupane-triterpene Carboxylic Acids from the Leaves of Acanthopanax trifoliatus
- Quinolone Alkaloids with Inhibitory Activity against Nuclear Factor of Activated T Cells from the Fruits of Evodia rutaecarpa(Pharmacognosy)
- Melampolides from the Leaves of Smallanthus sonchifolius and Their Inhibitory Activity of LPS-Induced Nitric Oxide Production
- Dependence of Malformation upon Gestational Age and Exposed Dose of Gamma Radiation
- Zeaxanthin Dipalmitate from Lycium chinense Fruit Reduces Experimentally Induced Hepatic Fibrosis in Rats
- A Novel Cerebroside from Lycii Fructus Preserves the Hepatic Glutathione Redox System in Primary Cultures of Rat Hepatocytes
- A New Monoterpenoid Glycoside from Myrica esculenta and the Inhibition of Angiotensin I-Converting Enzyme
- α-Glucosidase Inhibition Properties of Cucurbitane-Type Triterpene Glycosides from the Fruits of Momordica charantia
- Lupane Triterpene Glycosides from Leave of Acanthopanax koreanum and Their Cytotoxic Activity
- The Anti-oxidative and Anti-inflammatory Effects of Caffeoyl Derivatives from the Roots of Aconitum koreanum R. RAYMOND
- Phenylplropene A and B, New Inhibitors of Acyl-CoA : Cholesterol Acyltransferase Produced by Penicillium griseofulvum F1959
- Effects of Dimethylsulfoxide on Metabolism and Toxicity of Acetaminophen in Mice(Pharmacology)
- Sauchinone, a Lignan from Saururus chinensis, Attenuates CCl_4-Induced Toxicity in Primary Cultures of Rat Hepatocytes
- Inhibitory Effects of Ethaverine, a Homologue of Papaverine, on Monoamine Oxidase Activity in Mouse Brain
- (+)-α-Viniferin, a Stilbene Trimer from Caragana chamlague, Inhibits Acetylcholinesterase
- Two New Dammarane-Type Saponins from the Leaves of Panax ginseng
- Cytotoxic Alkaloids and a Flavan from the Bulbs of Crinum asiaticum var.japonicum
- Two New Neolignans from the Aerial Parts of Rodgersia podophylla
- Two New Acylated Iridoid Glucosides from the Aerial Parts of Paederia scandens
- Inhibitory Effect of TNF-α and IL-8 Secretion by Pimarane-Type Diterpenoids from Acanthopanax koreanum
- Alteration in Metabolism and Toxicity of Acetaminophen Upon Repeated Administration in Rats
- Hepatoprotective Dibenzylbutyrolactone Lignans of Torreya nucifera against CCl_4-Induced Toxicity in Primary Cultured Rat Hepatocytes(Pharmacognosy)
- Sauchinone, a Lignan from Saururus chinensis, Inhibits Staurosporine-Induced Apoptosis in C6 Rat Glioma Cells(Pharmacognosy)
- Gymnasterkoreayne G, a New Inhibitory Polyacetylene against NFAT Transcription Factor from Gymnaster koraiensis
- New Inhibitor against Nuclear Factor of Activated T Cells Transcription from Ribes fasciculatum var. chinense
- Oleanane Triterpenoids with Inhibitory Activity against NFAT Transcription Factor from Liquidambar formosana (Pharmacognosy)
- FORMATION OF 8-OXODEOXYGUANOSINE IN LIVER DNA AND HEPATIC INJURY BY PEROXISOME PROLIFERATOR CLOFIBRATE AND PERFLUORODECANOIC ACID IN RATS
- Anti-inflammatory Activity of the Synthetic Chalcone Derivatives : Inhibition of Inducible Nitric Oxide Synthase-Catalyzed Nitric Oxide Production from Lipopolysaccharide-Treated RAW 264.7 Cells(Pharmacology)
- Crinamine from Crinum asiaticum var. japonicum Inhibits Hypoxia Inducible Factor-1 Activity But Not Activity of Hypoxia Inducible Factor-2(Pharmacognosy)
- New Pyrano-Pyrone from Goniothalamus tamirensis Enhances the Proliferation and Differentiation of Osteoblastic MC3T3-E1 Cells
- A New Neuroprotective Pinusolide Derivative from the Leaves of Biota orientalis
- New Tetrahydrofuran-Type Sesquilignans of Saurus chinensis Root
- Effect of Dimethyl-4,4'-dimethoxy-5,6,5', 6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate (DDB) on Chemical-Induced Liver Injury
- Rhapontigenin Inhibited Hypoxia Inducible Factor 1 Alpha Accumulation and Angiogenesis in Hypoxic PC-3 Prostate Cancer Cells
- Effect of Taurine on Biliary Excretion and Metabolism of Acetaminophen in Male Hamsters(Toxicology)
- Stimulatory Activity of Lignans from Machilus thunbergii on Osteoblast Differentiation(Pharmacognosy)
- Effect of Neuroprotective Flavonoids of Agrimonia eupatoria on Glutamate-Induced Oxidative Injury to HT22 Hippocampal Cells
- Acteoside of Callicarpa dichotoma Attenuates Scopolamine-Induced Memory Impairments(Pharmacology)
- Effects of Carbon Tetrachloride Pretreat-ment on Hepato- and Nephrotoxicity of Halogenated Hydrocarbons in Mice
- IS-96 The prognostic value of the serum FSH and estradiol level in IVF cycles treated with GnRH Agonist
- UDPGT cDNA EXPRESSION AND UDPGT1 IN HUMAN LIVER
- Total Peroxynitrite Scavenging Capacity of Phenylethanoid and Flavonoid Glycosides from the Flowers of Buddleja officinalis
- Oleanolic Triterpene Saponins from the Roots of Panax bipinnatifidus
- The antioxidant effects of Joongpoongtang 05 on brain injury after transient focal cerebral ischemia in rats
- Antifibrotic activity of coumarins from Cnidium monnieri fruits in HSC-T6 hepatic stellate cells
- New non-quinone geldanamycin analogs from genetically engineered Streptomyces hygroscopicus
- Labdane-Type Diterpenoids from the Rhizomes of Hedychium coronarium Inhibit Lipopolysaccharide-Stimulated Production of Pro-inflammatory Cytokines in Bone Marrow-Derived Dendritic Cells
- (1S,2S,3E,7E,11E)-3,7,11,15-Cembratetraen-17,2-olide, a Cembrenolide Diterpene from Soft Coral Lobophytum sp., Inhibits Growth and Induces Apoptosis in Human Colon Cancer Cells through Reactive Oxygen Species Generation
- Plantagiolides I and J, Two New Withanolide Glucosides from Tacca plantaginea with Nuclear Factor-kappaB Inhibitory and Peroxisome Proliferator-Activated Receptor Transactivational Activities
- Diterpenoids from the Soft Coral Sinularia maxima and Their Inhibitory Effects on Lipopolysaccharide-Stimulated Production of Pro-inflammatory Cytokines in Bone Marrow-Derived Dendritic Cells
- Hirsutenone Directly Blocks Human ether-a-go-go Related Gene K+ Channels
- Antifibrotic Activity of Diarylheptanoids from Betula platyphylla toward HSC-T6 Cells
- Triterpenoid Saponins of Pulsatilla koreana Root Have Inhibition Effects of Tumor Necrosis Factor-α Secretion in Lipopolysaccharide-Induced RAW264.7 Cells
- Topical Application of Rosa multiflora Root Extract Improves Atopic Dermatitis-Like Skin Lesions Induced by Mite Antigen in NC/Nga Mice
- Quinone Derivatives from the Rhizomes of Acorus gramineus and Their Biological Activities