A New Neuroprotective Pinusolide Derivative from the Leaves of Biota orientalis
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概要
- 論文の詳細を見る
A new pinusolide derivative, 15-methoxypinusolidic acid (1), and another new isopimarane diterpene, ent-isopimara-15-en-3α,8α-diol (2) with three known diterpenes, lambertianic acid (3),' isopimara-8(9),15-dien-18-oic acid (4) and isopimara-7(8),15-dien-3β,18-diol (5) were isolated from the 90% MeOH fraction of Biota orientalis (L.) ENDL. (Cupressaceae) leaves. Chemical structures of 1-5 were elucidated by analyses of their spectral data, including the two-dimensional (2D) NMR technique. Compound 1 showed significant protective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cells.
- 公益社団法人日本薬学会の論文
- 2002-06-01
著者
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Kim Young
College of Pharmacy, Chungnam National University
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Sung Sang
College of Pharmacy, Seoul National University
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Kim Young
College Of Pharmacy And Research Institute Of Pharmaceutical Science Seoul National University
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Sung S
Seoul National Univ. Seoul Kor
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Koo Kyung
College Of Pharmacy Seoul National University
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Sung Sang
College Of Pharmacy Seoul National University
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Sung Sang
College Of Pharmacy And Research Institute Of Pharmaceutical Science Seoul National University
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Kim Young
Colledge of Pharmacy, Wonkwang University
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