Diterpenoids from the Soft Coral Sinularia maxima and Their Inhibitory Effects on Lipopolysaccharide-Stimulated Production of Pro-inflammatory Cytokines in Bone Marrow-Derived Dendritic Cells
スポンサーリンク
概要
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Nine new diterpenoids, termed sinumaximols A–I (1–3, 5–9, 12), together with three known compounds (4, 10, 11), were isolated from the methanol extract of the soft coral Sinularia maxima. Their structures were elucidated on the basis of extensive spectroscopic methods, including one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) and Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS). The isolated compounds were evaluated for their inhibitory effects on the lipopolysaccharide (LPS)-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells (BMDCs). Among them, compounds 2, 3, and 11 were potent inhibitors of LPS-stimulated interleukin-12 (IL-12) p40 with half-maximal inhibitory concentration (IC50) values ranging from 4.35±0.12 to 18.04±0.21 µM. Compounds 2, 3, and 11 showed moderate inhibitory activity on IL-6 production with IC50 values ranging from 17.72±0.31 to 59.77±2.34 µM.
著者
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Tai Bui
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology
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Koh Young-Sang
School of Medicine, Institute of Medical Sciences, Jeju National University
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Cuong Nguyen
Institute Of Archeology
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Luyen Bui
College of Pharmacy, Chungnam National University
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Thao Nguyen
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
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Kim Young
Colledge of Pharmacy, Wonkwang University
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Kiem Phan
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology
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Tai Bui
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
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Nam Nguyen
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
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Minh Chau
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology
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Quang Tran
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
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Chae Doobyeong
School of Medicine, Brain Korea 21 Program, and Institute of Medical Science, Jeju National University
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Cuong Nguyen
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
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Tung Pham
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)
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Kim Sohyun
School of Medicine, Brain Korea 21 Program, and Institute of Medical Science, Jeju National University
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Koh Young-Sang
School of Medicine, Brain Korea 21 Program, and Institute of Medical Science, Jeju National University
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Koh Young-Sang
School of Medicine and Brain Korea 21 Program, Jeju National Universit
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