Activation of Vasculogenic Progenitor Cells by ent-16.ALPHA.,17-Dihydroxy-kauran-19-oic Acid
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概要
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Vasculogenic progenitor cells (VPCs) circulate in the blood and have the ability to differentiate into endothelial cells that make up the lining of blood vessels. Therefore, VPC transplantation is a new strategy for the treatment of ischemic diseases. Because priming/preconditioning of VPCs before transplantation enhances their regenerative potential, the present study investigated whether ent-16α,17-dihydroxy-kauran-19-oic acid (DHK) isolated from Siegesbeckia pubescens could stimulate/activate VPCs in vitro. Therefore, the effect of DHK (1—100 μM concentration) on the proliferation, migration, and tube forming of VPCs was examined in various systems, and related signaling pathways were identified. DHK treatment significantly increased the proliferation, migration, and tube formation of VPCs in a dose-dependent manner. Phosphorylation of extracellular signal-regulated kinase (ERK)1/2 and Akt was significantly increased by DHK, but chemical inhibitors against ERK1/2 (U0126) and Akt (LY294002) significantly attenuated DHK-enhanced proliferation, migration, and tube formation of VPCs. Collectively, these results indicated that DHK shows promise as a novel VPC primer/activator.
著者
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Jeong Yun-mi
Department Of Dermatology Seoul National University College Of Medicine
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Park Sang
Department Of Anatomy Seoul National University College Of Medicine
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Sung Jong-hyuk
Department Of Applied Bioscience Cha University
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Sung Sang
College Of Pharmacy And Research Institute Of Pharmaceutical Science Seoul National University
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Park So-Hyun
Departmentof Applied Bioscience, CHA University
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Suh Wonhee
College of Pharmacy, Ajou University
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Sung Jong-Hyuk
Departmentof Applied Bioscience, CHA University
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Chung Hyung
Departmentof Applied Bioscience, CHA University
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Kim Ji
Department of Advanced Materials Engineering, Sangju National University, Kyeongbuk 742-711, Korea
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Park Sang
Department of Biomedical Science, CHA University
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Kim Ji
Departmentof Applied Bioscience, CHA University
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