Cloning and Identification of a New Antimicrobial Protein, Salvic, from Human Salivary Gland(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)
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概要
- 論文の詳細を見る
From a subtracted cDNA library of human salivary gland a C77-91 gene totally unknown to date was named as Salvic that expresses 46 amino acids peptide (pI=9.45) possessing an antimicrobial activity on E. coli. Salvic is consisted of a typical hydrophobic amino acid rich domain in the N-terminus, a cluster of basic amino acids, carbohydrate attachment sites, a possible transglutaminase catalyzed crosslinking site, and multiple consensus sequences of phosphorylation site in the C-terminus. Western blot analysis using the monospecific antibody to the synthetic Salvic peptide showed strong interacting proteins in the extracts from submandibular gland and parotid saliva, and the immunohistochemical staining detected a strong positive reaction in the cytoplasmic secretory granules of interlobular ductal cells of salivary gland. The Salvic was also distributed in the human sebaceous gland and prostate. These data suggest that the identification of Salvic may add further understanding of greater role of salivary proteins providing innate immunity by protecting and stabilizing the mucosal epithelium in the maintaining homeostasis of oral mucosa.
- 硬組織再生生物学会の論文
著者
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PARK Sang
Department of Interaction Design. Graduate School of Techno Design. Kookmin University
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Chung Soo
Department Of Diagnostic Radiology Yongin Severance Hospital Research Institute Of Radiological Scie
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Park Sang
Department Of Anatomy Seoul National University College Of Medicine
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KIM Yeon
Department of Biotechnology, Graduate School of Engineering, Osaka University
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Chung Soo
Department Of Oral Pathology College Of Dentistry Kangnung National University:coram Bioscience
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CHI Je
Departments of Pathology Seoul National University College of Medicine
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LEE Suk
Department of Information Statistics, ChungNam National University
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Chi Je
Department Of Patholgy College Of Medicine Seoul National University
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Park Sang
Department Of Biochemistry
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Lee Suk
Department Of Oral Pathology College Of Dentistry Kangnung National University
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Kim Yeon
Department Of Oral Pathology College Of Dentistry Kangnung National University:coram Bioscience
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Kim Yeon
Department Of Biology College Of Science Yonsei University
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Lee Suk
Department Of Information Statistics Chungnam National University
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Lee Suk
Department Of Industrial Engineering Korea Advanced Institute Of Science And Technology
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