A Concise Synthesis of Licochalcone E and Its Regio-Isomer, Licochalcone F
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概要
- 論文の詳細を見る
Licochalone E is one of the retrochalcones isolated from Glycyrrhiza inflata which shows potent cytotoxicty against human tumor cell lines. Biological studies suggested that topoisomerase I inhibition correlates with cytotoxic properties. Other research revealed that licochalcone E modulats the nuclear factor (NF)-kB and Bcl-2 families to induce endothelial cell apoptosis. Since licochalcone E has been isolated recently, synthetic information on this compound has not been reported yet. Therefore we report the concise synthesis of licochalcone E and its regioisomer, tentatively called licochalcone F, by employing Claisen rearrangement for key intermediate synthesis.
- 社団法人 日本薬学会の論文
著者
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Cha Jeong-heon
Department Of Oral Biology Bk21 Project Oral Science Research Center Yonsei University College Of De
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Na Younghwa
College of Pharmacy, Catholic University of Daegu
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Yoon Ho-Geun
Department of Biochemistry and Molecular Biology, Center for Chronic Metabolic Disease Research, Col
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Kwon Youngjoo
College of Pharmacy, Ewha Womans University
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Na Younghwa
College Of Pharmacy Catholic University Of Daegu
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Yoon Ho-geun
Department Of Biochemistry And Molecular Biology Center For Chronic Metabolic Disease Research Colle
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Kwon Youngjoo
College of Pharmacy and Division of Life & Pharmaceutical Sciences, Ewha Womans University
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