Solvolysis Study of Cycliciminomitomycins

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概要

• 論文の詳細を見る

• The solvolysis rates for the substituted C (7)-cyclohexylamino- or C (8)-cyclohexyliminomitomycins 8-19 were determined in buffered methanolic solutions (0.06 M bis-Tris・HCl, pH : 5.5) at 25℃ and then compared with mitomycin C (1) and porfiromycin. Kinetic studies showed that C (8)-cyclohexyliminomitomycins 8-13 underwent solvolysis 150-230 times faster than mitomycin C (1) to give C (1)-methoxymitosene products. The solvolysis rates were slightly faster than that reported for 6. The C (7)-(2'-hydroxy) cyclohexylaminomitomycins 16-19 exhibited comparable solvolysis rates with 1 and porfiromycin.

• 公益社団法人日本薬学会の論文
• 2007-03-01

著者

• Na Younghwa

  College of Pharmacy, Catholic University of Daegu

• Na Younghwa

  College Of Pharmacy Catholic University Of Daegu

関連論文

• A Concise Synthesis of Licochalcone E and Its Regio-Isomer, Licochalcone F
• Solvolysis Study of Cycliciminomitomycins
• Study on the Synthesis and Cytotoxicity of New Quinophenoxazine Derivatives

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