Spontaneous Ultra-Weak Photon Emission and Delayed Luminescence during Carbon Tetrachloride-Induced Liver Injury and Repair in Mouse

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概要

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• Spontaneous ultra-weak photon emission and delayed luminescence were measured from the mouse liver injured by carbon tetrachloride (CCl_4), a hepatotoxic chemical. After carbon tetrachloride in olive oil (4 ml/kg) was injected intraperitoneally into ICR mouse, spontaneous photon emission and delayed luminescence using metal halide lamp was measured from the excised liver. Twenty-four hours after injection, spontaneous photon emission from the livers was 69.3±21.2 counts/min/cm^2, which was two times higher than that from controls of 29.5±5.9 counts/min/cm^2. However, 72 hr after injection, spontaneous photon emission from the livers was lowered to 37.0±14.9 counts/min/cm^2. These observations were closely correlated with those of the activities of aspartate aminotransferase (AST/GOT) and alanine aminotransferase (ALT/GPT), which were released in the course of hepatocellular death. Delayed luminescence also showed clear distinction in its time course of relaxation between the carbon tetrachloride-treated and control groups. On the basis of these observations, we suggest that these photon emissions are involved in the process of death and/or proliferation of liver cells after acute exposure to carbon tetrachloride with sublethal doses. Further, these photon emissions might be originated from the process of lipid peroxidation and consequent radical scavenging by antioxidant enzymes in injured liver tissue. This model study might provide a basis for the analysis of hepatotoxicant induced liver injury and repair by means of measurements of the photon emissions.

• 公益社団法人日本薬学会の論文
• 2005-04-01

著者

• LEE Seung

  College of Pharmacy, Yeungnam University

• Kim Yong-ung

  School Of Physics Seoul National University

• Kim Yong

  College Of Pharmacy And Research Institute Of Pharmaceutical Sciences Seoul National University

• Soh Kwang

  Biomedical Physics Lab., School of Physics, Seoul National University

• LEE Byung-Cheon

  Biomedical Physics Lab., School of Physics, Seoul National University

• Lee Seung

  College Of Pharmacy Seoul National University

• Soh Kwang

  Biomedical Physics Lab. School Of Physics Seoul National University

• Lee Seung

  College Of Pharmacy And Cbitrc Chungbuk National University

• Lee Byung-cheon

  Biomedical Physics Laboratory 25-414 School Of Physics Seoul National University

• Kim Jungdae

  Biomedical Physics Laboratory 25-414, School of Physics, Seoul National University

• Lim Jaekwan

  Biomedical Physics Laboratory 25-414, School of Physics, Seoul National University

• Lee Byung

  Biomedical Physics Laboratory 25-414, School of Physics, Seoul National University

• Cheun Byeung

  Department of Molecular Biology, College of Medicine, Kyung Hee University

• Lim Jaekwan

  Biomedical Physics Laboratory 25-414 School Of Physics Seoul National University

• Cheun Byeung

  Department Of Molecular Biology College Of Medicine Kyung Hee University

• Kim Yong

  College of Electronics and Electrical Engineering, Kyungwon University, San 65, Bokjung-dong, Soojung-gu, Seongnam City, Kyunggi-do 461-701, Korea

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