Mushroom Tyrosinase Inhibition Activity of Some Chromones

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概要

• 論文の詳細を見る

• Currently, aloesin is used in the cosmetic industry as a whitening agent because it inhibits tyrosinase activity. Aloesin is a C-glycosylated chromone compound isolated from aloe, and it is difficult to synthesize because of C-glycosyl moiety in the molecule. The purpose of this study is to search for a new chromone compound which is easy to synthesize and which posesses stronger tyrosinase inhibitory activity than aloesin. Fourteen chromone derivatives were synthesized and screened for their mushroom-tyrosinase inhibitory activity. 5-Methyl-7-methoxy-2-(2'-benzyl-3'-oxobutyl)chromone (15) showed the strongest activity among tested compounds. Its activity was not only stronger than aloesin, but also stronger than arbutin and kojic acid. The kinetic analysis revealed a competitive inhibition of 15 with tyrosinase for the L-tyrosine binding site.

• 公益社団法人日本薬学会の論文
• 2002-03-01

著者

• Park Jeong

  Res. Inst. Of Pharmaceutical Sciences Coll. Of Pharmacy Seoul National Univ.

• LEE Seung

  College of Pharmacy, Yeungnam University

• PARK Jeong

  College of Pharmacy, Seoul National University

• Park Jeong

  College Of Pharmacy And Research Institute Of Pharmaceutical Sciences Seoul National University

• PARK Man

  College of Pharmacy, Seoul National University

• Park Man

  韓国

• Park M

  College Of Pharmacy Seoul National University

• Park Man

  College Of Pharmacy Seoul National University

• PIAO Long

  College of Pharmacy Seoul National University

• PARK Hyang

  College of Pharmacy, Seoul National University

• PARK Yun

  College of Pharmacy, Seoul National University

• Park Yun

  College Of Pharmacy Seoul National University

• Lee S

  Ewha Womans Univ. Seoul Kor

• Park Hyang

  College Of Pharmacy Seoul National University

• Lee Seung

  College Of Pharmacy And Cbitrc Chungbuk National University

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