Agents Protecting against Sepsis from the Roots of Angelica dahurica(Pharmacognosy)

概要

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In the course of isolating agents preventing sepsis from the EtOAc extract of the roots of Angelica dahurica, four known furanocoumarins, isoimperatorin (1), oxypeucedanin (2), (±)-byakangelicin (3), and (+)-oxypeucedanin hydrate (4), were isolated as active compounds based on the in vivo assay model of sepsis induced by lipopolysaccharide (LPS) and o-galactosamine (_D-GalN). Among them, 3 showed the highest survival rate (100% with a dose of 30 mg/kg versus 20% for the control experiment) and decreased the plasma levels of tumor necrosis factor-α and alanine aminotransferase in mice adminstered LPS/_D-GalN.
社団法人日本薬学会の論文
2005-02-01