Antiallergic Activity of Ginsenoside Rh2(Pharmacognosy)
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概要
- 論文の詳細を見る
The antiallergic activities of ginsenosides, which were isolated from acid-treated ginseng (Panax ginseng, Araliacene), and their metabolites by human intestinal bacteria were measured. Ginsenoside Rh2, which is a main metabolite, had the most potent inhibitory activity on β-hexosaminidase release from RBL-2H3 cells and in the passive cutaneous anaphylaxis reaction. The inhibitory activity of ginsenoside Rh2 was more potent than that of disodium cromoglycate, a commercial antiallergic drug. This compound showed membrane stabilizing action upon differential scanning calorimetry and inhibited nitric oxide (NO) and prostaglandin E_2 (PGE_2) in lipopolysaccharide-stimulated RAW cells. However, this ginsenoside Rh2 did not inhibit the activation of hyaluronidase and did not scavenge active oxygen. These results suggest that ginsenoside Rh2 can exhibit antiallergic activity originating from cell membrane-stabilizing activity and antiinflammatory activity by the inhibition of NO and PGE_2 production.
- 公益社団法人日本薬学会の論文
- 2003-11-01
著者
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Kim Dong-hyun
College Of Pharmacy Kyung Hee University
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PARK Eun-Kyung
College of Pharmacy, Kyung Hee University
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HAN Myung
Department of Food and Nutrition, Kyung Hee University
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CHOO Min-Kyung
College of Pharmacy, Kyung Hee University
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Han Myung
Department Of Food And Nutrition Kyung Hee University
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Park Eun-kyung
韓国
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Park Eun-kyung
College Of Pharmacy Kyung Hee University
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Park Eun
Department Of Biochemistry Kon Kuk University
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Kim Deog
College Of Pharmacy Kyung Hee University
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Choo Min-kyung
College Of Pharmacy Kyung Hee University
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Choo Min-kyung
韓国
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Kim D‐h
College Of Pharmacy Kyung Hee University
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Kim Dong-hee
Korea Research Institute Of Bioscience And Biotechnology
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Park E‐k
College Of Pharmacy Kyung Hee University
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Kim Do-hoon
Department Of Psychiatry College Of Medicine Institute Of Natural Medicine Hallym University
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Kim Dong-hyun
Department Of Life And Nanopharmaceutical Sciences And Department Of Pharmaceutical Science Kyung He
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KIM Eun-Jin
College of Pharmacy, Kyung Hee University
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Kim Eun-jin
College Of Pharmacy Kyung Hee University
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Kim D‐h
Department Of Psychiatry College Of Medicine Institute Of Natural Medicine Hallym University
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Kim D‐h
Taegu Univ. Kyungbuk Kor
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Kim Dong-hyun
College Of Pharmacy
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