肥満型及び痩せ型Zucker糖尿病肥満ラットの視床下部におけるオレキシンA及びニューロペプタイドYの発現変化(解剖学)
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概要
- 論文の詳細を見る
本研究では, レプチン受容体遺伝子に突然変異を持つ肥満型及び痩せ型Zucker糖尿病肥満(ZDF)ラットの視床下部におけるオレキシンA及びニューロペプタイドYの発現変化を検討した.肥満型及び痩せ型ZDFラットの体重平均値は, 生後28日齢及び70日齢において有意に異なる値を示した.しかしながら, 生後14日齢では雌雄とも差異は認められなかった.オレキシンAの発現は, 生後14, 28, 及び70日齢において, 肥満型及び痩せ型ZDFラット間で雌雄とも有意差は見られなかった.一方, ニューロペプタイドYは発現は, 生後28日齢及び70日齢において, 雌雄とも肥満型が高い値を示したが, 生後14日齢では両者に差異は認められなかった.これらの結果から, オレキシンA及びニューロペプタイドYとも, 離乳期前の生後14日齢では雌雄ともZDFラット肥満型における食物摂取に対して役割を演じていないのに対して, ニューロペプタイドYは離乳後の生後28日齢及び70日齢において, ZDFラットの肥満に対して主要な役割を担っていることが示唆される.
- 社団法人日本獣医学会の論文
- 2005-07-25
著者
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SEONG Je
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
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LEE In
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
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YOON Yeo
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
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Seong Je
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Seong Je
韓国
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Park Eun
Department Of Biochemistry Kon Kuk University
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Lee I
Seoul National Univ. Seoul
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Lee I.
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Yoon Yeo
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Kim Jin
Physical Therapy College Of Rehabilitation Daegu University
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Park E
Department Of Veterinary Histology College Of Veterinary Medicine Seoul National University
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Li Hua
Hallym Univ. Chuncheon
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Park Eun
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And School Of Agricultural Bio
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LEE Heungshik
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterina
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YI Seong
Anatomy, College of Veterinary Medicine, Kyungpook National University
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Yi S
Anatomy College Of Veterinary Medicine Kyungpook National University
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Yoon Yeo-sung
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Lee Heungshik
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Lee In
Department Of Agronomy College Of Agriculture And Life Sciences Kyungpook National University
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Seong Je
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Yi Sun
Department Of Anatomy And Cell Biology College Of Veterinary Medicine And Bk21 Program For Veterinar
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Lee In
Department Of Aerospace Engineering
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Kim J.S.
Physical Therapy, College of Rehabilitation, Daegu University
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Lee H.S.
Department of Anatomy and Cell Biology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University
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Yoon Y.S.
Department of Anatomy and Cell Biology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University
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