Polypyrimidine Tract-Binding Protein Is Involved in Regulation of Albumin Synthesis in Response to Food Intake
スポンサーリンク
概要
- 論文の詳細を見る
Our recent study demonstrates that polypyrimidine tract-binding protein (PTB), which is a sequence specific RNA-binding protein, attenuates albumin synthesis in a cell-free translation system. In this study, the effects of food intake on regulation of albumin synthesis through binding of PTB to albumin messenger RNA (mRNA) were investigated. Rats were divided into 1 of 3 groups: fed; fasted for 36h; or fasted for 36h and then refed for 24h. No significant differences in albumin mRNA levels were found among fed, fasted and refed rats. However, a decrease in the proportion of albumin mRNA associated with polysomes was identified in fasted rats. Furthermore, UV-cross linking analysis demonstrated that levels of albumin mRNA-PTB complex were increased in liver extracts from fasted rats. No significant differences in PTB levels in liver homogenate were found among the experimental groups. However, PTB level in the cytoplasmic fraction was higher in fasted rats than in fed rats. In refed rats, PTB level in the cytoplasmic fraction returned to a level comparable to that in fed rats, but was inhibited by treatment with rapamycin, a mammalian target of rapamycin (mTOR) inhibitor. These results suggest that localization of PTB is regulated by food intake through mTOR signaling, and alterations in level of albumin mRNA-PTB complex play a role in mediating the effects of food intake on albumin synthesis in the rat liver.
- 日本ビタミン学会の論文
著者
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MIYAMOTO Ken-ichi
Department of Pharmacology and Pharmaceutics, Graduate School of Natural Science and Technology, Kan
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OKA Tatsuzo
Department of Nutritional Chemistry, University of Tokushima School of Medicine
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Oka Tatsuzo
徳島大学 ヘルスバイオサイエンス研究部分子栄養学
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Oka Tatsuzo
Department Of Veterinary Medicine Faculty Of Agriculture Kagoshima University
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KOBAYASHI Yukiko
Department of Biochemistry, University of Shizuoka, School of Pharmaceutical Sciences
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Miyamoto Ken-ichi
Department Of Molecular Nutrition Institute Of Health Biosciences The University Of Tokushima Gradua
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Oka Tatsuzo
Department Of Nutrition School Of Medicine The University Of Tokushima
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SEGAWA Hiroko
Department of Molecular Nutrition, Institute of Health Biosciences, University of Tokushima Graduate
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Ito Mikiko
Department of Veterinary Public Health, Faculty of Veterinary Medicine, Hokkaido University
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Tatsumi Sawako
Department Of Molecular Nutrition Institute Of Health Biosciences The University Of Tokushima Gradua
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Segawa Hiroko
Department Of Molecular Nutrition Institute Of Health Bioscience University Of Tokushima Graduate Sc
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Segawa Hiroko
Department Of Molecular Nutrition Institute Of Health Biosciences The University Of Tokushima Gradua
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Morita Kyoko
Department Of Clinical Nutrition School Of Medicine The University Of Tokushima
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KUWAHATA Masashi
Department of Molecular Nutrition, Institute of Health Biosciences, The University of Tokushima Grad
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KURAMOTO Yasuko
Department of Molecular Nutrition, Institute of Health Biosciences, The University of Tokushima Grad
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SAWAI Yukiko
Department of Molecular Nutrition, Institute of Health Biosciences, The University of Tokushima Grad
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AMANO Saki
Department of Molecular Nutrition, Institute of Health Biosciences, The University of Tokushima Grad
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TOMOE Yuka
Department of Molecular Nutrition, Institute of Health Biosciences, The University of Tokushima Grad
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KIDO Yasuhiro
Department of Food Sciences and Nutritional Health, Faculty of Human Environment, Kyoto Prefectural
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Kido Yasuhiro
Division Of Applied Life Science Graduate School Of Life And Environmental Sciences Kyoto Prefectura
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Ito Mikiko
Department Of Molecular Nutrition Institute Of Health Biosciences The University Of Tokushima Gradua
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Ito M
徳島大学医学部
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Kido Yasuhiro
Department Of Food Sciences And Nutritional Health Faculty Of Human Environment Kyoto Prefectural Un
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Amano Saki
Department Of Molecular Nutrition Institute Of Health Biosciences The University Of Tokushima Gradua
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Tomoe Yuka
Department Of Molecular Nutrition Institute Of Health Biosciences The University Of Tokushima Gradua
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Sawai Yukiko
Department Of Molecular Nutrition Institute Of Health Biosciences The University Of Tokushima Gradua
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Minamitani Kanshi
Department Of Molecular Nutrition Institute Of Health Biosciences The University Of Tokushima Gradua
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Ito Mikiko
Department Of Health Promotion Science Division Of Health Sciences Osaka University Graduate School
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Kobayashi Yukiko
Division Of Applied Life Science Graduate School Of Life And Environmental Sciences Kyoto Prefectura
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Kobayashi Yukiko
Department Of Biochemistry University Of Shizuoka School Of Pharmaceutical Sciences
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Kobayashi Yukiko
Department Of Food Sciences And Nutritional Health Faculty Of Human Environment Kyoto Prefectural Un
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Kuramoto Yasuko
Department Of Molecular Nutrition Institute Of Health Biosciences The University Of Tokushima Gradua
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Miyamoto Ken-ichi
Department Of Applied Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University
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Segawa Hiroko
Nutritional Science Department Of Nutrition School Of Medicine Tokushima University
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Kido Yasuhiro
Department Of Food Sciences And Nutritional Health Faculty Of Human Environment Kyoto Prefectural Un
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Miyamoto Ken-ichi
Department Of Molecular Nutrition Institute Of Health Biosciences University Of Tokushima Graduate S
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Shimamura Yasuhiro
Department Of Nutrition Science Graduate School Of Life And Environmental Sciences Kyoto Prefectural University
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Kuwahata Masashi
Department Of Nutrition Science Graduate School Of Life And Environmental Sciences Kyoto Prefectural University
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Koayashi Yukiko
Department of Food Sciences and Nutritional Health, Faculty of Human Environment, Kyoto Prefectural University
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Krdo Yasuhiro
Department of Food Sciences and Nutritional Health, Faculty of Human Environment, Kyoto Prefectural University
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OKA Tatsuzo
Department of Frontier Veterinary Science, Faculty of Agriculture, Kagoshima University
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