Aerobic and Anaerobic Biotransformation of Bile Acids by Escherichia coli (II) : No Conversion of α-Muricholic Acid by 7α-Hydroxysteroid Dehydrogenase of E. coli

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概要

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• The effect of Escherichia coli K-12 on the transformation of hyocholic acid, α-muricholic acid, β-muricholic acid and 3α,7 β,12α-trihydroxy-5β-cholanoic acid was examined in aerobic and anaerobic cultures for 4 days and the activities were compared with those on cholic acid and chenodeoxycholic acid. Hyocholic acid was dehydrogenated, but to a lesser extent than cholic acid or chenodeoxycholic acid. However, α-muricholic acid, which has a 7α-hydroxyl group, was not dehydrogenated even after 4 days. This was confirmed by experiments using a cell-free crude enzyme preparation and by gas chromatographic analysis of bile acids in the medium culture. β-Muricholic acid and 3α,7β,12α-trihydroxy-5 β-cholanoic acid were not changed by Esherichia coli K-12.

• 日本ビフィズス菌センターの論文
• 2005-04-01

著者

• Yamada Kazuo

  Division of Circulation and Respiration, The Research Institute of Environmental Medicine, Nagoya Un

• YAMADA Kazuo

  Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute

• Yamada Kazuo

  Division Of Circulation And Respiration The Research Institute Of Environmental Medicine Nagoya Univ

• KIDO Yasuhiro

  Department of Food Sciences and Nutritional Health, Faculty of Human Environment, Kyoto Prefectural

• Yamada K

  Division Of Medical Biochemistry Department Of Pathophysiological And Therapeutic Science School Of

• Yamada Kazuo

  Laboratory For Molecular Psychiatry Riken Brain Science Institute

• Kido Yasuhiro

  Faculty Of Human Environment Kyoto Prefectural University

• Kido Yasuhiro

  Department Of Food Sciences And Nutritional Health Faculty Of Human Environment Kyoto Prefectural Un

• Kido Yasuhiro

  Departments Of Surgery And Gastroenterology Fujisawa Municipal Hospital

• Uchida K

  Tottori Univ. Fac. Medicine

• OGURA Yoshio

  Division of Medical Biochemistry, Department of Pathophysiological and Therapeutic Science, School o

• YAMAGA Nobuo

  Division of Medical Biochemistry, Department of Pathophysiological and Therapeutic Science, School o

• SUZUKI Takao

  Division of Functional Radiation Science, Research Center for Bioscience and Technology, Tottori Uni

• KIMURA Koji

  Division of Functional Radiation Science, Research Center for Bioscience and Technology, Tottori Uni

• UCHIDA Kiyohisa

  Division of Medical Biochemistry, Department of Pathophysiological and Therapeutic Science, School o

• Yamaga N

  Tottori Univ. Fac. Medicine

• Yamaga Nobuo

  Division Of Medical Biochemistry Department Of Pathophysiological And Therapeutic Science School Of

• Ogura Yoshio

  Division Of Medical Biochemistry Department Of Pathophysiological And Therapeutic Science School Of

• Kido Y

  National Agricultural Research Center For Kyushu Okinawa Region

• Kimura Koji

  Division Of Functional Radiation Science Research Center For Bioscience And Technology Tottori Unive

• Suzuki Takao

  Division Of Functional Radiation Science Research Center For Bioscience And Technology Tottori University

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