Can Coenzyme Q_<10> Lead to Improvement of Essential Hypertension? : A Long-Term Case Study

概要

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Many hypertensive patients are continuously prescribed various antihypertensive drugs despite the undesirable side effects such as nausea, dizziness, and vertigo. To decrease the use of cardiovascular drugs for preventing these side effects, alternative pharmacotherapy with supplements such as coenzyme Q_<10> has been extensively studied. However, the effects of coenzyme Q_<10> based on clinical trials involving relatively small patient numbers have been varied, and the impact on the cardiovascular system remains to be clarified. Here we report a case of 67-year-old woman with essential hypertension (maximum systolic/diastolic blood pressure: 155/100mmHg) who had been prescribed candesartan cilexetil as an outpatient for about 5 years. Regardless of the treatment, the symptoms were not relieved, and the systolic and diastolic blood pressures gradually increased with age. However, after weeklong supplementation with coenzyme Q_<10>, her diastolic blood pressure returned to normal, and so did her systolic blood pressure after month-long supplementation. Subsequently, she completely ceased taking candesartan. Thus, coenzyme Q_<10> supplementation may be effective for selected patients with essential hypertension. This should be investigated further in randomized controlled trials.
公益社団法人日本薬学会の論文
2008-10-01