Inhibitory Effect of Magnosalin Derived from Flos magnoliae on Tube Formation of Rat Vascular Endothelial Cells during the Angiogenic Process

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概要

• 論文の詳細を見る

• An aqueous water extract of Flos magnoliae, a Japanese Sino-medicine, inhibits angiogenesis in adjuvant-induced mouse pouch granuloma. Magnosalin (MSA) and magnoshinin(MSI), neolignans isolated from magnolia, have a crucial role in the anti-angiogenic effect of magnolia (Kimura et al., Int. Arch. Allergy Appl. Immunol., 93,365 (1990); Phytother. Res., 6,209 (1992)). We investigated the effects of these neolignans on tube formation of endothelial cells (EC) cultured in type I collagen gel during the angiogenic process. MSA (0.1-10 μM), MSI (0.23-7 μM) and corticosterone (CS : 0.3-30 μM) inhibited fetal bovine serum (FBS)-stimulated tube formation in a concentration-dependent manner. Their 30% inhibitory concentration (IC_<30>, 95% confidence limits) values were 0.51 (0.20-1.27) for MSA, 8.14 (2.48-26.7) for MSI and 3.65 μM (2.47-5.40) for CS, respectively. MSA and MSI (1-3 μM) also inhibited interleukin (IL)-1α-stimulated tube formation in a concentration-dependent manner. Their IC_<50> values (95% confidence limits) were 1.22 (1.01-1.47) for MSA and 0.74 μM (0.24-2.31) for MSI against a submaximal concentration (69 pM) of IL-1α-stimulated tube formation. Their inhibitory effects on the action of IL-1α were non-competitive. These results demonstrate that MSA inhibited FBS-stimulated tube formation with a greater potency than MSI. The inhibitory effect of MSA on the action of FBS differed from that on the action of IL-1α.

• 社団法人日本薬学会の論文
• 1996-10-15

著者

• Kimura Masayasu

  Department of Cardiovascular Medicine, Medical Bioregulation, Yamaguchi University School of Medicin

• 木村 郁子

  富山医科薬科大学大学院薬学研究科臨床薬理学

• 木村 郁子

  富山医科薬科大学 大学院薬学研究科臨床薬理学講座

• KIMURA Ikuko

  Department of Chemical Pharmacology Faculty of Pharmaceutical Sciences, Toyama medical and Pharmaceu

• Kimura M

  Health Science Center At San Antonio The University Of Texas

• KOBAYASHI Shinjiro

  (Present Address)Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokuriku University

• Inaba Kazuhiko

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut

• Inaba Kazuhiko

  北陸大学 薬 薬理

• Kimura I

  Toyama Medical And Pharmaceutical Univ. Toyama Jpn

• Kimura Ikuko

  Department Of Chemical Pharmacology Faculty Of Phrmaceutical Sciemes Toyama Medical And Pharmaceutic

• Kimura M

  Tsumura & Co. Ltd. Ibaraki Jpn

• Kimura Masayasu

  Department Of Cardiovascular Medicine Medical Bioregulation Yamaguchi University School Of Medicine

• Kimura Masayasu

  Department Of Chemical Pharmacology Faculty Of Phrmaceutical Sciemes Toyama Medical And Pharmaceutic

• Kimura I

  Department Of Ophthalmology Keio University School Of Medicine

• Kimura Ikuko

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut

• Kobayashi S

  Kyoritsu Coll. Pharmacy

• 木村 郁子

  Department Of Clinical Pharmacology Graduate School Of Pharmaceutical Sciences Toyama Medical And Ph

• Kimura Ikuko

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical & Pharmace

• Kobayashi Shinjiro

  Department Of Clinical Pharmacology Faculty Of Pharmaceutical Sciences Hokuriku University:organizat

• Kimura Masayasu

  Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti

• Kimura Ikuko

  Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University

• 木村 郁子

  富山医科薬科大学大学院薬学研究科 臨床薬理学講座

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