The Streptozocin-Diabetic State Depresses Saliva Secretion Stimulated by Pilocarpine and Noradrenaline in Mice
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概要
- 論文の詳細を見る
We investigated the influence of the streptozocin (STZ)-diabetic state on the dose-response curves for salivary flow and protein content in saliva stimulated by pilocarpine and noradrenaline in mice. The diabetic state increased the relative weights of parotid and sublingual salivary glands but not the weight of submandibular glands, despite body weight loss. In the dose-response curves, (1) the maximal responses to stimulation with pilocarpine and noradrenaline on salivary flow, and with noradrenaline on protein content in saliva, were depressed by the diabetic state, and (2) the value of the 50% effective dose for salivary flow with pilocarpine, but not with noradrenaline, was decreasingly altered by diabetic mice. These results suggest that xerostomia, one of the complications of non-insulin-dependent diabetes mellitus, is caused in part by muscarinic and adrenergic receptor dysfunction in the salivary glands.
- 社団法人日本薬学会の論文
- 1996-03-15
著者
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Chen Fu-jun
中華人民共和国
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Kimura Masayasu
Department of Cardiovascular Medicine, Medical Bioregulation, Yamaguchi University School of Medicin
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KIMURA Ikuko
Department of Chemical Pharmacology Faculty of Pharmaceutical Sciences, Toyama medical and Pharmaceu
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Kimura M
Health Science Center At San Antonio The University Of Texas
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Inaba Kazuhiko
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Inaba Kazuhiko
北陸大学 薬 薬理
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Chen F‐j
Department Of Chemical Pharmacology Faculty Of Phrmaceutical Sciemes Toyama Medical And Pharmaceutic
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Kimura I
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Kimura Ikuko
Department Of Chemical Pharmacology Faculty Of Phrmaceutical Sciemes Toyama Medical And Pharmaceutic
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Kimura M
Tsumura & Co. Ltd. Ibaraki Jpn
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Kimura Masayasu
Department Of Cardiovascular Medicine Medical Bioregulation Yamaguchi University School Of Medicine
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Kimura Masayasu
Department Of Chemical Pharmacology Faculty Of Phrmaceutical Sciemes Toyama Medical And Pharmaceutic
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CHEN Fu-Jun
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmace
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MIYAMOTO Hidetoshi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmace
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Kimura I
Department Of Ophthalmology Keio University School Of Medicine
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Miyamoto Hidetoshi
Department Of Chemical Pharmacology Faculty Of Phrmaceutical Sciemes Toyama Medical And Pharmaceutic
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Kimura Ikuko
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical & Pharmace
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Kimura Masayasu
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Kimura Ikuko
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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CHEN Fu-Jun
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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MIYAMOTO Hidetoshi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
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