Inhibitory Effect of Isoliquiritin, a Compound in Licorice Root, on Angiogenesis in Vivo and Tube Formation in Vitro
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概要
- 論文の詳細を見る
A water extract of licorice root inhibits granuloma angiogenesis in adjuvant-induced chronic inflammation (Phytother. Res., 5,195,1991). The present study has investigated the effects of licorice-derived compounds on granuloma angiogenesis. Isoliquiritin (0.31-3.1mg/kg), a licorice-derived flavonoid, inhibited the carmine content of granuloma tissue 50-fold greater than licorice extract. Glycyrrhizin (20-80mg/kg), a licorice-derived saponin, inhibited carmine content with a weak potency. The licorice extract (0.01-1mg/ml) also inhibited tube formation from vascular endothelial cells in a concentration-dependent manner. From the chemical structure-activities of used licorice-derived flavonoids (0.1-100μM), their potencies for anti-tube formation were in the order isoliquiritigenin>isoliquiritin>liquiritigenin≫isoliquiritin-apioside. Glycyrrhizin (0.1-100μM) and glycyrrhetinic acid (0.1-10μM) increased tube formation. A glycyrrhizin (82μg/ml)-induced increase in tube formation was inhibited by isoliquiritin. The combined effect of a mixture of 82μg/ml glycyrrhizin and 4.2μg/ml isoliquiritin, a similar concentration ratio to their yield ratio in the licorice extract, corresponded to the effect of 100μg/ml extract. In conclusion, the anti-angiogenic effect of licorice extract depended on the anti-tube formation effect of isoliquiritin.
- 社団法人日本薬学会の論文
- 1995-10-15
著者
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宮本 隆行
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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古林 伸二郎
北陸大学薬学部薬理学講座
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木村 郁子
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmace
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木村 正康
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmace
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木村 正康
Hscsaテキサス大学
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Inaba Kazuhiko
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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Inaba Kazuhiko
北陸大学 薬 薬理
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古林 伸二郎
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences Toyama Medical and Pharmaceu
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Kimura I
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Kimura Ikuko
Department Of Chemical Pharmacology Faculty Of Phrmaceutical Sciemes Toyama Medical And Pharmaceutic
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Kimura I
Department Of Ophthalmology Keio University School Of Medicine
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Kimura Ikuko
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceut
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