MOLECULAR PHARMACOLOGICAL STUDIES ON DRUG-RECEPTOR COMPLEXES SYSTEM IN DRUG ACTION:VI. THE MODE OF ACTION OF ORGANOPHOSPHORYL CHOLINE <I>IN VITRO</I> AND <I>IN VIVO</I>
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概要
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During studies on acetylcholine-its receptor complexes system in drug action, the authors designed the anticholinergic agent of more fitting structure to acetylcholine (ACh) receptor (1), and synthesized the new compound of dicyclohexyl thionothiolphosphorylcholine (NP245) (2). This compound NP245 has more potency 2.43 times than <I>d</I>-tubocurarine (<I>d</I>-TC) as curare-like action, 3/100 times of neostigmine as anticholinesterase action, and 1/1000 times of atropine as antispasmodic action. Particularly, combining selectively with ACh receptor, it has played the part of a useful tool for researching of the ACh receptor (3). This paper reports experiments on the mode of action of NP245 <I>in vitro</I> and <I>in vivo</I>, moreover, on its metabolic fate in rats.
- 公益社団法人 日本薬理学会の論文
著者
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木村 正康
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmace
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橋本 久邦
Departments Of Pharmacology And Anesthesiology Hamamatsu University School Of Medicine:(present Addr
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室 郁子
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Toyama
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池田 浩子
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Toyama
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橋本 久邦
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Toyama
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木村 正康
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Toyama
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