和漢薬作用に関する薬学的基礎研究(第3報) : 漢薬牛黄の水溶性分画における平滑筋収縮性物質の薬理学的態度について

概要

論文の詳細を見る
The water-soluble fraction of the Chinese drug, "Bezoar Orientale" was deproteinized with trichloroacetic acid, the glacial acetic acid solution of its fraction was extracted with ether, and the ether extract was decolorized with animal charcoal. The ether extract was purified by ethanol and a crude peptide-like substance was obtained. The aqueous solution of this substance showed pH 5. The thin-layer chromatogram of the substance gave two Ninhydrinpositive spots which had absorption maximum at around 280 mμ. This substance showed a marked contraction of digestive smooth muscles and this activity is selectively inhibited by atropine. The substance effects transitory fall of blood pressure in rabbits and this effect is also inhibited by atropine. In other words, this substance has an acetylcholine-like pharmacological activity.
公益社団法人日本薬学会の論文
1966-10-25