和漢薬作用に関する薬学的基礎研究(第4報) : 漢薬牛黄の含有成分間の胆汁排出作用における協力効果について平滑筋機能に関する研究その2

概要

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The cholagogic action of the crude drug, oriental bezoar, was examined by dividing the action into contraction of the gall bladder and relaxation of Oddi's sphincter. It was thereby found that, among the components of bezoar, the substance that causes contraction of the smooth muscle, found earlier, was the only one that showed contraction of the gall bladder and Oddi's sphincter, and most of other bite acid salts showed a relaxing effect. Deoxycholate showed the strongest a relaxing action on Oddi's sphincter and this was proved to be the principle of the cholagogic action of bezoar. The substance which contracts the smooth muscle was found to inhibit the relaxing action of deoxycholate in the gall bladder and to take part in the mechanism of contractive excretion. It was concluded from these results that pharmacologucally antagonistic substances, acting on the same point, formed a functionally co-operating system to effect cholagogic activity.
公益社団法人日本薬学会の論文
1967-05-25