和漢薬作用に関する薬学的基礎研究(第11報)動物性和漢薬の白血球遊走抑制効果における複合作用とその有効成分

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Combined effect of drugs of animal origin (musk, bezoar, bufotalis) was examined by Boyden's method, using guinea pig polymorphonuclear leucocytes for inhibitory effect on leucocyte migration. A migration-inhibitory activity was found in musk, bezoar, ninhydrin reaction-positive substances musk peptide fraction (MP) extracted from musk, and smooth muscle contracting substances extracted from bezoar. MP was the most effective of substances tested. The active component of MP was determined to be a peptide from the fact that the activity was lost by tryptic hydrolysis and that the molecular weight was estimated to be about 1000,using ultrafiltration and Sephadex. The combined action of musk-bezoar was an antagonistic type. That of muskbufotalis was not observed but that of bezoar-bufotalis was a synergistic type. The apparent combined action of muskbezoar-bufotalis was not observed but interactions described above seem at least to be included.
社団法人日本薬学会の論文
1978-04-25