The Effects of the Serotonin_<1A> Receptor Agonist Buspirone on Tolbutamide-Induced Hypoglycemia in Rats
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概要
- 論文の詳細を見る
The effects of the serotonin_<1A> (5-HT_<1A>) receptor agonist buspirone on hypoglycemia elicited by tolbutamide were investigated in rats. Buspirone, at doses not affecting plasma glucose levels, inhibited the hypoglycemic effects of tolbutamide. The inhibitory effects of buspirone on tolbutamide-induced hypoglycemia were antagonized by the 5-HT_<1A> receptor antagonist pindolol. As tolbutamide is known to induce hypoglycemia by facilitating insulin release, the effects of buspirone on a tolbutamide-induced increase in serum insulin levels were also studied. However, buspirone did not affect tolbutamide-induced insulin release. Adrenodemedullation inhibited the effects of buspirone. These results suggest that buspirone inhibits tolbutamide-induced hypoglycemia mediated by the 5-HT_<1A> receptor, and adrenaline release may be involved in the effects of buspirone.
- 社団法人日本薬学会の論文
- 1995-09-15
著者
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山田 潤
神戸薬科大学 薬理
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木村 郁子
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmace
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堀坂 和敬
Department Of Pharmacology Kobe Pharmaceutical University
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杉本 由美
神戸薬科大学、薬理学研究室
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山田 潤
Department of Pharmacology, Kobe Pharmaceutical University
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杉本 由美
Department of Pharmacology, Kobe Pharmaceutical University
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Yamada J
Kobe Pharmaceutical Univ. Kobe Jpn
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木村 郁子
Department Of Pharmacology Kobe Pharmaceutical University
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山田 潤
Department Of Pharmacology Kobe Pharmaceutical University
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杉本 由美
Department of Ophthalmology, Faculty of Medical Science, University of Fukui
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