Effects of Insulin and Adrenalectomy on Elevation of Serum Leptin Levels Induced by 5-Hydroxytryptophan in Mice(Pharmacology)
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概要
- 論文の詳細を見る
We previously reported that a serotonin precursor 5-hydroxytryptophan (5-HTP) increases serum leptin levels in mice. In this study, we studied the effects of insulin and adrenalectomy on hyperleptinemia induced by 5-HTP. Co-administration of insulin significantly increased hyperleptinemia elicited by 5-HTP. 5-HTP itself increased serum insulin levels. Adrenalectomy, which depletes corticosterone, did not abolish hyperleptinemic effects of 5-HTP. These results suggest that insulin may participate in hyperleptinemic effects of 5-HTP and that the involvement of corticosterone in effects of 5-HTP may be probably small.
- 公益社団法人日本薬学会の論文
- 2003-10-01
著者
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山田 潤
神戸薬科大学 薬理
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YAMADA Jun
Department of Surgical Oncology, Faculty of Medicine, the University of Tokyo
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杉本 由美
神戸薬科大学、薬理学研究室
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Sugimoto Yoshihiko
Department Of Ophthalmology Faculty Of Medical Science University Of Fukui
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SUGIMOTO Yumi
Department of Pharmacology, Kobe Pharmaceutical University
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Sugimoto Y
Dep. Of Pharmacology Kobe Pharmaceutical Univ.
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Sugimoto Yumi
Department Of Pharmacology Kobe Pharmaceutical University
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Sugimoto Yumi
Laboratory Of Pharmacology Department Of Clinical Pharmacy Yokohama College Of Pharmacy:department O
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Yamada J
Kobe Pharmaceutical Univ. Kobe Jpn
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Sugimoto Yoko
Department Of Ophthalmology Faculty Of Medical Science University Of Fukui
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山田 潤
Department Of Pharmacology Kobe Pharmaceutical University
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杉本 由美
Departmment Of Pharmacology Faculty Of Pharmaceutical Siences Okayama University
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Sugimoto Yumi
Dep. Of Pharmacology Kobe Pharmaceutical Univ.
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Sugimoto Yumi
Department Of Pharmacology Kobe Women's College Of Pharmacy.
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UJIKAWA Masanori
Department of Pharmacology, Kobe Pharmaceutical University
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Ujikawa Masanori
Department Of Pharmacology Kobe Pharmaceutical University
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Yamada J
Lab. Of Pharmacology Dep. Of Clinical Pharmacy Yokohama Coll. Of Pharmacy
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Sugimoto Y
Department Of Ophthalmology Faculty Of Medical Science University Of Fukui
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Yamada Jun
Department Of Pharmacology Kobe Pharmaceutical University
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Yamada Jun
Department Of Electrical And Electronics Engineering Aichi Institute Of Technology
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