Involvement of Serotonin in Zimelidine-Induced Hyperglycemia in Mice

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概要

• 論文の詳細を見る

• Effects of a selective serotonin reuptake inhibitor, zimelidine, on plasma glucose was studied in mice. Zimelidine dose-dependently induced hyperglycemia, although it did not change insulin levels. To determine the involvement of the serotonergic system in zimelidine-induced hyperglycemia, effects of the 5-HT depleter p-chlorophenylalanine(pCPA) were examined. pCPA significantly reduced zimelidine-induced hyperglycemia. This suggests that zimelidine-induced hyperglycemia is mediated by the serotonergic system through its 5-HT reup-take inhibition.

• 公益社団法人日本薬学会の論文
• 1999-11-15

著者

• 山田 潤

  神戸薬科大学 薬理

• YAMADA Jun

  Department of Surgical Oncology, Faculty of Medicine, the University of Tokyo

• 杉本 由美

  神戸薬科大学、薬理学研究室

• Sugimoto Yoshihiko

  Department Of Ophthalmology Faculty Of Medical Science University Of Fukui

• Inoue K

  Tokyo Research Laboratories Kowa Co. Ltd.

• SUGIMOTO Yumi

  Department of Pharmacology, Kobe Pharmaceutical University

• Sugimoto Y

  Dep. Of Pharmacology Kobe Pharmaceutical Univ.

• Sugimoto Yumi

  Department Of Pharmacology Kobe Pharmaceutical University

• Sugimoto Yumi

  Laboratory Of Pharmacology Department Of Clinical Pharmacy Yokohama College Of Pharmacy:department O

• Yamada J

  Kobe Pharmaceutical Univ. Kobe Jpn

• Sugimoto Yoko

  Department Of Ophthalmology Faculty Of Medical Science University Of Fukui

• Inoue K

  Gifu Pharmaceutical University

• Inoue K

  Department Of Pharmacology Kobe Pharmaceutical University

• INOUE Kiyo

  Department of Pharmacology, Kobe Pharmaceutical University

• 山田 潤

  Department Of Pharmacology Kobe Pharmaceutical University

• 杉本 由美

  Departmment Of Pharmacology Faculty Of Pharmaceutical Siences Okayama University

• Sugimoto Yumi

  Dep. Of Pharmacology Kobe Pharmaceutical Univ.

• Sugimoto Yumi

  Department Of Pharmacology Kobe Women's College Of Pharmacy.

• Inoue Kiyo

  Department Of Pharmacology Kobe Pharmaceutical University

• 井上 勝央

  名古屋市立大学大学院薬学研究科薬物動態制御学分野

• Yamada J

  Lab. Of Pharmacology Dep. Of Clinical Pharmacy Yokohama Coll. Of Pharmacy

• Sugimoto Y

  Department Of Ophthalmology Faculty Of Medical Science University Of Fukui

• Yamada Jun

  Department Of Pharmacology Kobe Pharmaceutical University

• Yamada Jun

  Department Of Electrical And Electronics Engineering Aichi Institute Of Technology

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