INDOLEACETIC ACID-INDUCED HYPOTHERMIA AND CHANGES IN SEROTONIN METABOLISM IN MICE

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概要

• 論文の詳細を見る

• The effects of the tryptamine metabolite, indoleacetic acid (IAA) on body temperature and serotonin (5-HT) metabolism in mice were investigated. IAA at 300 mg/kg i. p. induced significant hypothermia in mice. It caused a remarkable decrease in concentration of total tryptophan (TRP) and a considerable increase in free TRP in serum. IAA increased 5-HT, 5-hydroxyindoleacetic acid and TRP in the brain, but decreased 5-HT synthesis in the brain. The 5-HT antagonist, methysergide and the 5-HT depleter, p-chlorophenylalanine did not affect IAA-induced hypothermia.

• 公益社団法人日本薬学会の論文

著者

• 山田 潤

  神戸薬科大学 薬理

• YAMADA Jun

  Department of Surgical Oncology, Faculty of Medicine, the University of Tokyo

• 杉本 由美

  神戸薬科大学、薬理学研究室

• Sugimoto Yoshihiko

  Department Of Ophthalmology Faculty Of Medical Science University Of Fukui

• SUGIMOTO Yumi

  Department of Pharmacology, Kobe Pharmaceutical University

• Sugimoto Y

  Dep. Of Pharmacology Kobe Pharmaceutical Univ.

• Sugimoto Yumi

  Department Of Pharmacology Kobe Pharmaceutical University

• Sugimoto Yumi

  Laboratory Of Pharmacology Department Of Clinical Pharmacy Yokohama College Of Pharmacy:department O

• Yamada J

  Kobe Pharmaceutical Univ. Kobe Jpn

• Sugimoto Yoko

  Department Of Ophthalmology Faculty Of Medical Science University Of Fukui

• 山田 潤

  Department Of Pharmacology Kobe Pharmaceutical University

• HORISAKA Kazuyoshi

  Department of Pharmacology, Kobe Pharmaceutical University

• Horisaka Kazuyoshi

  Department Of Pharmacology Kobe Pharmaceutical University

• 杉本 由美

  Departmment Of Pharmacology Faculty Of Pharmaceutical Siences Okayama University

• Sugimoto Yumi

  Dep. Of Pharmacology Kobe Pharmaceutical Univ.

• Sugimoto Yumi

  Department Of Pharmacology Kobe Women's College Of Pharmacy.

• Yamada J

  Lab. Of Pharmacology Dep. Of Clinical Pharmacy Yokohama Coll. Of Pharmacy

• Sugimoto Y

  Department Of Ophthalmology Faculty Of Medical Science University Of Fukui

• Yamada Jun

  Department Of Pharmacology Kobe Pharmaceutical University

• Yamada Jun

  Department Of Electrical And Electronics Engineering Aichi Institute Of Technology

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