The Tricyclic Antidepressant Clomipramine Increases Plasma Glucose Levels of Mice
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概要
- 論文の詳細を見る
Effects of the tricyclic antidepressant clomipramine on plasma glucose levels in mice were studied. Clomipramine at doses ranging 5 – 20 mg/kg elicited significant hyperglycemia in mice. Hyperglycemia elicited by clomipramine was not reduced by pretreatment with the 5-hydroxytryptamine (5-HT) depleter p-chlorophenylalanine. The 5-HT1/2/5/7-receptor antagonist methysergide and the 5-HT2A/2B/2C-receptor antagonist LY 53857 enhanced clomipramine-induced hyperglycemia, while the 5-HT1A/1B-receptor antagonist (−)-propranolol and the 5-HT3/4-receptor antagonist tropisetron did not affect it. The 5-HT2B/2C-receptor antagonist SB 206553 facilitated hyperglycemia induced by clomipramine, although the 5-HT2A-receptor antagonist ketanserin was without effect. Clomipramine-induced hyperglycemia was reduced by prior adrenalectomy. These results suggest that clomipramine induces hyperglycemia in mice by blocking the 5-HT2B and/or 5-HT2C receptors, which results in facilitation of adrenaline release.
- 社団法人 日本薬理学会の論文
- 2003-09-01
著者
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山田 潤
神戸薬科大学 薬理
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YAMADA Jun
Department of Surgical Oncology, Faculty of Medicine, the University of Tokyo
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杉本 由美
神戸薬科大学、薬理学研究室
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Sugimoto Yoshihiko
Department Of Ophthalmology Faculty Of Medical Science University Of Fukui
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Inoue K
Tokyo Research Laboratories Kowa Co. Ltd.
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SUGIMOTO Yumi
Department of Pharmacology, Kobe Pharmaceutical University
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Sugimoto Y
Dep. Of Pharmacology Kobe Pharmaceutical Univ.
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Sugimoto Yumi
Department Of Pharmacology Kobe Pharmaceutical University
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Sugimoto Yumi
Laboratory Of Pharmacology Department Of Clinical Pharmacy Yokohama College Of Pharmacy:department O
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Yamada J
Kobe Pharmaceutical Univ. Kobe Jpn
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Sugimoto Yoko
Department Of Ophthalmology Faculty Of Medical Science University Of Fukui
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Inoue K
Gifu Pharmaceutical University
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Inoue K
Department Of Pharmacology Kobe Pharmaceutical University
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INOUE Kiyo
Department of Pharmacology, Kobe Pharmaceutical University
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山田 潤
Department Of Pharmacology Kobe Pharmaceutical University
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杉本 由美
Departmment Of Pharmacology Faculty Of Pharmaceutical Siences Okayama University
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Sugimoto Yumi
Dep. Of Pharmacology Kobe Pharmaceutical Univ.
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Sugimoto Yumi
Department Of Pharmacology Kobe Women's College Of Pharmacy.
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Inoue Kiyo
Department Of Pharmacology Kobe Pharmaceutical University
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井上 勝央
名古屋市立大学大学院薬学研究科薬物動態制御学分野
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Yamada J
Lab. Of Pharmacology Dep. Of Clinical Pharmacy Yokohama Coll. Of Pharmacy
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Sugimoto Y
Department Of Ophthalmology Faculty Of Medical Science University Of Fukui
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Yamada Jun
Department Of Pharmacology Kobe Pharmaceutical University
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Yamada Jun
Department Of Electrical And Electronics Engineering Aichi Institute Of Technology
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