Involvement of Leptin in Hypophagia Induced by the Serotonin Precursor 5-Hydroxytryptophan (5-HTP) in Mice(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
We previously demonstrated that a serotonin (5-HT) precursor 5-hydroxytryptophan (5-HTP) increases serum leptin levels in mice. It was reported that administration of 5-HTP elicits hypophagia in rodents and humans. In the present study, we examined involvement of leptin in 5-HTP-elicited decreases in the milk intake of fasted mice. Serum leptin levels increased with increases in milk intake in mice, while 5-HTP strongly decreased milk intake in fasted mice compared to that in the control group. Serum leptin levels in fasted mice treated with 5-HTP were similar to those control mice after milk intake. As leptin is a powerful anorectic signal, 5-HTP-induced anorexia may be mediated by facilitation of leptin secretion.
- 公益社団法人日本薬学会の論文
- 2006-03-01
著者
-
山田 潤
神戸薬科大学 薬理
-
YAMADA Jun
Department of Surgical Oncology, Faculty of Medicine, the University of Tokyo
-
杉本 由美
神戸薬科大学、薬理学研究室
-
Sugimoto Yoshihiko
Department Of Ophthalmology Faculty Of Medical Science University Of Fukui
-
SUGIMOTO Yumi
Department of Pharmacology, Kobe Pharmaceutical University
-
Sugimoto Y
Dep. Of Pharmacology Kobe Pharmaceutical Univ.
-
Sugimoto Yumi
Department Of Pharmacology Kobe Pharmaceutical University
-
Sugimoto Yumi
Laboratory Of Pharmacology Department Of Clinical Pharmacy Yokohama College Of Pharmacy:department O
-
Yamada J
Kobe Pharmaceutical Univ. Kobe Jpn
-
Sugimoto Yoko
Department Of Ophthalmology Faculty Of Medical Science University Of Fukui
-
山田 潤
Department Of Pharmacology Kobe Pharmaceutical University
-
杉本 由美
Departmment Of Pharmacology Faculty Of Pharmaceutical Siences Okayama University
-
Sugimoto Yumi
Dep. Of Pharmacology Kobe Pharmaceutical Univ.
-
Sugimoto Yumi
Department Of Pharmacology Kobe Women's College Of Pharmacy.
-
UJIKAWA Masanori
Department of Pharmacology, Kobe Pharmaceutical University
-
Ujikawa Masanori
Department Of Pharmacology Kobe Pharmaceutical University
-
Yamada J
Lab. Of Pharmacology Dep. Of Clinical Pharmacy Yokohama Coll. Of Pharmacy
-
Sugimoto Y
Department Of Ophthalmology Faculty Of Medical Science University Of Fukui
-
Yamada Jun
Department Of Pharmacology Kobe Pharmaceutical University
-
Yamada Jun
Department Of Electrical And Electronics Engineering Aichi Institute Of Technology
関連論文
- Targeting Id1 and Id3 inhibits peritoneal metastasis of gastric cancer
- Clonidine 誘発高血糖に対するセロトニン系抗不安薬の影響
- Serotonin_2 (5-HT_2) Receptor Agonist 1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane (DOI) Inhibits Chlorpromazine-and Haloperidol-Induced Hypothermia in Mice
- The Effects of the Serotonin_ Receptor Agonist Buspirone on Tolbutamide-Induced Hypoglycemia in Rats
- Bilateral Optic Disc Macroaneurysm Associated with Acquired Vascular Loop
- Antiallergic Effect of Flavonoid Glycosides Obtained from Mentha pipertita L.
- The 5-HT_2 Receptor Antagonist Reduces Immobility of Mice Treated with the Atypical Antidepressant Mianserin in the Forced Swimming Test
- Fluvoxamine の強制水泳試験における不動時間短縮作用と serotonin 受容体との関連について
- Immunohistochemical Study of Apoptosis of Lens Epithelial Cells in Human and Diabetic Rat Cataracts
- Postoperative Changes Over Time in Size of Anterior Capsulorrhexis in Phacoemulsification/Aspiration
- Histology of Anterior Capsule Edges Produced by CCC and DC
- Cell permeable ROS scavengers, Tiron and Tempol, rescue PC12 cell death caused by pyrogallol or hypoxia/reoxygenation
- Fluvoxamine の強制水泳試験における作用の性差に関する検討
- 強制水泳試験における dopamine 再取り込み阻害薬の不動時間短縮作用とセロトニン_2受容体サブタイプとの関連
- Marble burying behavior に対する leptin の影響
- Dopamine 再取り込み阻害薬の強制水泳試験における影響
- 選択的セロトニン再取り込み阻害薬の生体内動態と薬効
- 選択的セロトニン再取り込み阻害薬 fluoxetine の強制水泳試験における影響と5-HT_4受容体の関与について
- 7系統マウスにおける Marble burying behavior の系統差について
- Desipramineの強制水泳試験における不動時間短縮作用に対する5-HT_2受容体拮抗薬の影響
- 5-HIT遊離薬p-chloroamphetamine誘発体温上昇に対するdopamine受容体拮抗薬の影響
- Tandospirone の epinephrine 誘発高血糖に対する影響
- Early gastric cancer with Krukenberg tumor and review of cases of intramucosal gastric cancers with Krukenberg tumor
- The Tricyclic Antidepressant Clomipramine Increases Plasma Glucose Levels of Mice
- Involvement of Serotonin in Zimelidine-Induced Hyperglycemia in Mice
- Effects of Peripheral Administration of 5-Hydroxytryptamine (5-HT) on 2-Deoxy-D-glucose-Induced Hyperphagia in Rats(Pharmacology)
- The 5-HT^ Receptor Agonist m-Chlorophenylpiperazine(mCPP)Inhibits 2-Deoxy-D-glucose(2-DG)-Induced Hyperphagia in Rats
- Effects of a Nitric Oxide Synthase Inhibitor on Hypophagia Induced by the Peripheral 5-HT Receptor Agonists, α-Methyl-5-hydroxytryptamine and 5-Carboxamidotryptamine in Rats
- Inhibitory Effects of a Nitric Oxide Synthase Inhibitor, N^G-Nitro-L-arginine Methyl Ester (L-NAME), on 2-Deoxy-D-glucose-Induced Hyperglycemia in Rats
- The Effects of Peripheral Serotonin_2 (5-HT_2) and Serotonin_3 (5-HT_3) Receptor Agonists on Blood Glucose Levels in Rats
- Involvement of Leptin in Hypophagia Induced by the Serotonin Precursor 5-Hydroxytryptophan (5-HTP) in Mice(Pharmacology)
- Inhibitory Effects of the 5-HT_ Receptor Agonist Buspirone on Stress-Induced Hyperglycemia in Mice : Involvement of Insulin and a Buspirone Metabolite, 1-(2-Pyrimidinyl) piperazine (1-PP)(Pharmacology)
- Effects of the Serotonergic Anxiolytic Buspirone on Plasma Glucose and Glucose-Induced Hyperglycemia in Mice
- Effects of Insulin and Adrenalectomy on Elevation of Serum Leptin Levels Induced by 5-Hydroxytryptophan in Mice(Pharmacology)
- Leptin Inhibits Food Intake without Affecting Brain NOx Levels in Food-Deprived Mice(Pharmacology)
- Effects of the Serotonin and Noradrenaline Reuptake Inhibitor (SNRI) Milnacipran on Marble Burying Behavior in Mice(Pharmacology)
- SIMULTANEOUS DETERMINATION OF TRYPTOPHAN AND ITS METABOLITES IN BIOLOGICAL SAMPLES BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY WITH FLUOROMETRIC DETECTION
- EFFECTS OF ω-AMINOSULFONIC ACIDS ON LIPID METABOLISM IN DIETARY HYPERLIPIDEMIC RATS
- EFFECT OF TRYPTAMINE ON THE BEHAVIOR OF MICE
- ELEVATION OF SERUM INDOLEACETIC ACID LEVELS IN RATS WITH EXPERIMENTAL LIVER FAILURE
- INDOLEACETIC ACID-INDUCED HYPOTHERMIA AND CHANGES IN SEROTONIN METABOLISM IN MICE
- The 5-HT_1A Receptor Agonist 8-Hydroxy-2-di-n-(propylamino)tetralin(8-OH-DPAT)Induces Hyperglucagonemia in Rats
- Effect of Docosahexaenoic Acid-Fortified Chlorella vulgaris Strain CK22 on the Radial Maze Performance in Aged Mice
- Study on Physical Properties of Plasma Generated by YAG Laser in Liquid
- Intraperitoneal administration of paclitaxel solubilized with poly(2-methacryloxyethyl phosphorylcholine-co n-butyl methacrylate) for peritoneal dissemination of gastric cancer
- Protective Effects of Cyclo(L-Leu-L-Tyr) against Postischemic Myocardial Dysfunction in Guinea-Pig Hearts
- Spectral Evidence and Kinetics for Formation of the Sitting-Atop Complex of Copper(II) Ion with 5, 10, 15, 20-Tetraphenylporphyrin in Acetonitrile
- Effect of the 5-HT_ Receptor Agonist 1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane (DOI) on Plasma Glucose and Glucagon Levels of Rats
- Al, Cu and W Oxide Fine Particles Produced by Discharge Explosions
- The Printing Mask for Electron Diffraction Photographs
- Effects of the 5-HT_2 Receptor Antagonist, Ritanserin on Hyperthermia and Depletion of 5-HT in Frontal Cortex Induced by a 5-HT Releasing Drug, p-Chloroamphetamine(PCA)in Mice
- Dissecting Aneurysm of the Middle Cerebral Artery Manifesting as Subarachnoid Hemorrhage and Hemorrhagic Infarctions : Case Report
- FUNDAMENTAL STUDIES ON PHYSIOLOGICAL AND PHARMACOLOGICAL ACTIONS OF L-ASCORBATE 2-SULFATE. VI. EFFECTS OF L-ASCORBATE 2-SULFATE ON LIPID METABOLISM IN GUINEA PIGS
- FUNDAMENTAL STUDIES ON PHYSIOLOGICAL AND PHARMACOLOGICAL ACTIONS OF L-ASCORBATE 2-SULFATE. V. ON THE HYPOLIPIDEMIC AND ANTIATHEROSCLEROTIC EFFECTS OF L-ASCORBATE 2-SULFATE IN RABBITS
- HYPOTHERMIC EFFECT OF ω-AMINOSULFONIC ACIDS
- Impedance of a Partially Ionized Cecium Plasma
- Production and Physical Properties of Cesium Plasma by Resonance Absorption
- Cell migration from the ganglionic eminence to the neocortex investigated by labeling nuclei with UV irradiation Via a fiber-optic cable
- Contribution of Dissociative Recombination to a Cesium Plasma Produced by Resonance Absorption
- FUNDAMENTAL STUDIES ON PHYSIOLOGICAL AND PHARMACOLOGICAL ACTIONS OF L-ASCORBATE 2-SULFATE. I. ON THE HYPOLIPIDEMIC EFFECTS
- Physical Properties of Dense Plasma Produced by XeCl Excimer Laser in High-Pressure Argon Gases
- On the Surface Character of Chert Clasta
- Spectroscopic Measurement of High-Pressure Argon Plasma Produced by Excimer Laser
- Effects of serotonin on blood glucose and insulin levels of glucose- and streptozotocin-treated mice.
- The Effects of the Serotonin1A Receptor Agonist Buspirone on the Blood Glucose and Pancreatic Hormones in Rats.
- The involvement of serotonergic and dopaminergic systems in hypothermia induced in mice by intracerebroventricular injection of serotonin.
- P-65 蓮子心のアルカロイドおよび誘導体の合成と薬理活性(ポスター発表の部)