Effects of a Nitric Oxide Synthase Inhibitor on Hypophagia Induced by the Peripheral 5-HT Receptor Agonists, α-Methyl-5-hydroxytryptamine and 5-Carboxamidotryptamine in Rats

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概要

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• We investigated the effects of the nitric oxide (NO) synthase inhibitor, N^G -nitro-L-arginine methyl ester (L-NAME) on hypophagia in rats elicited by α-methyl-5-hydroxytryptamine (α-methyl-5-HT) and 5-carboxamidotryptamine (5-CT) which are suggested to be mediated by the peripheral 5-HT_<2A> and 5-HT_7 receptor, respectively. Both α-methyl-5-HT and 5-CT apparently inhibited food intake in food-deprived rats. L-NAME significantly enhanced α-methyl-5-HT-elicited hypophagia, while it inhibited 5-CT-elicited hypophagia. These results suggest that NO is differentialy related to α-methyl-5-HT and 5-CT-induced hypophagia and that NO may play a role in hypo- and hyperphagia.

• 公益社団法人日本薬学会の論文
• 2000-12-01

著者

• 山田 潤

  神戸薬科大学 薬理

• YAMADA Jun

  Department of Surgical Oncology, Faculty of Medicine, the University of Tokyo

• 杉本 由美

  神戸薬科大学、薬理学研究室

• Sugimoto Yoshihiko

  Department Of Ophthalmology Faculty Of Medical Science University Of Fukui

• SUGIMOTO Yumi

  Department of Pharmacology, Kobe Pharmaceutical University

• Sugimoto Y

  Dep. Of Pharmacology Kobe Pharmaceutical Univ.

• Sugimoto Yumi

  Department Of Pharmacology Kobe Pharmaceutical University

• Sugimoto Yumi

  Laboratory Of Pharmacology Department Of Clinical Pharmacy Yokohama College Of Pharmacy:department O

• Yamada J

  Kobe Pharmaceutical Univ. Kobe Jpn

• YOSHIKAWA Tomoko

  Department of Industrial Chemistry, Faculty of Engineering, Seikei University

• Sugimoto Yoko

  Department Of Ophthalmology Faculty Of Medical Science University Of Fukui

• 山田 潤

  Department Of Pharmacology Kobe Pharmaceutical University

• Yoshikawa T

  Institute For Medicinal Resources University Of Tokushima

• NOMA Toshiko

  Department of Pharmacology, Kobe Pharmaceutical University

• Noma Toshiko

  Department Of Pharmacology Kobe Pharmaceutical University

• 杉本 由美

  Departmment Of Pharmacology Faculty Of Pharmaceutical Siences Okayama University

• Sugimoto Yumi

  Dep. Of Pharmacology Kobe Pharmaceutical Univ.

• Sugimoto Yumi

  Department Of Pharmacology Kobe Women's College Of Pharmacy.

• Yamada J

  Lab. Of Pharmacology Dep. Of Clinical Pharmacy Yokohama Coll. Of Pharmacy

• Sugimoto Y

  Department Of Ophthalmology Faculty Of Medical Science University Of Fukui

• Yamada Jun

  Department Of Pharmacology Kobe Pharmaceutical University

• Yoshikawa T

  Kitasato Univ. Kanagawa Jpn

• Yoshikawa Tomoko

  Department Of Biology University Of Virginia

• Yamada Jun

  Department Of Electrical And Electronics Engineering Aichi Institute Of Technology

• Yoshikawa Tetsushi

  Laboratory Of Virology Research Institute For Disease Mechanism And Control Nagoya University Graduate School Of Medicine

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