Effects of serotonin on blood glucose and insulin levels of glucose- and streptozotocin-treated mice.
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概要
- 論文の詳細を見る
Effects of serotonin (5-HT) on plasma glucose and serum insulin levels were studied in mice. In normal mice, 5-HT induced a dose-dependent hypoglycemia and an increase in serum insulin levels. 5-HT significantly inhibited glucose-induced hyperglycemia and increased glucose-stimulated insulin release. However, in streptozotocin-induced diabetic mice, 5-HT changed neitheir the glucose nor insulin levels. These results strongly suggest that 5-HT-induced hypoglycemia is brought on by increasing serum insulin levels.
- 公益社団法人 日本薬理学会の論文
著者
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Sugimoto Yumi
Department Of Pharmacology Kobe Pharmaceutical University
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Takeuchi Naoko
Department Of Bioresource Science Graduate School Of Biosphere Science Hiroshima University
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Horisaka Kazuyoshi
Department Of Pharmacology Kobe Pharmaceutical University
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Watanabe Yoshiko
Department Of Cardiology Nishitokyo Central General Hospital
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Yamada Jun
Department Of Electrical And Electronics Engineering Aichi Institute Of Technology
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Kimura Ikuko
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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SUGIMOTO Yumi
Department of Pharmacology, Kobe Women's College of Pharmacy
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TAKEUCHI Naoko
Department of Pharmacology, Kobe Women's College of Pharmacy
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