Stopped-flow investigation of antioxidant activity of tocopherols.

スポンサーリンク

概要

• 論文の詳細を見る

• It was observed by ESR measurement that the oxidation of α-, β-, γ-, and δ-tocopherols (vitamin E) with a stable phenoxyl radical in benzene immediately gives corresponding tocopheroxyl radicals. The rates of reaction of α-, β-, γ-, and δ-tocopherols with the stable phenoxyl radical in ethanol solution have been determined spectrophotometrically using stopped-flow technique, as a model reaction of tocopherols with unstable free radicals (ROO·, RO·, and HO·) in biological systems. The second-order rate constants obtained are (5.12±0.36)×10<SUP>3</SUP> (α-Toc), (2.24±0.04)×10<SUP>3</SUP> (β-Toc), (2.42±0.16)×10<SUP>3</SUP> (γ-Toc), and (0.51±0.01)×10<SUP>3</SUP> (δ-Toc), M<SUP>−1</SUP> s<SUP>−1</SUP> in ethanol at 25.0 °C. The relative rates agree well with those obtained from studies of the reactivities of tocopherols toward poly(styrylperoxyl) and galvinoxyl radicals by O<SUB>2</SUB> consumption and by ESR method, respectively. The results suggest that the relative reactivities, that is, relative antioxidant activities of tocopherols do not depend on the kinds of unstable free radicals reacted.

• 公益社団法人 日本化学会の論文

著者

• Mukai Kazuo

  Department Of Chemistry Faculty Of Science Ehime University

• Ishizu Kazuhiko

  Department Of Chemistry Faculty Of Science Ehime University

• Watanabe Yoshiko

  Department Of Cardiology Nishitokyo Central General Hospital

• Uemoto Yuichi

  Department of Chemistry, Faculty of Science, Ehime University

関連論文

• Endovascular stent grafting for abdominal aortic aneurysm
• Heat Capacity Study of the Doping Effect of Paramagnetic Radicals on the Organic Spin-Peierls System (p-CyDOV Radical Crystal)
• Heat Capacity Study of the Doping Effect of Paramagnetic Radicals on the Organic Spin-Peierls System (p-CyDOV Radical Crystal)
• PE-465 The Prevalence of Ischemic Heart Disease in Patients with Aortic Aneurysms and Arteriosclerosis Obliterans(Peripheral circulation/Vascular disease(05)(H),Poster Session(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society
• High-Field Magnetization Study of the Doping Effect of Magnetic Impurity on the Organic Spin-Peierls System : p-CyDOV Radical Crystal
• Magnetism of a Two-Dimensional Weak-Ferromagnetic Organic Radical Crystal,1,3,5-Tripheny1-6-Oxoverdazyl
• Evaluation of the Efficacy of Left Internal Thoracic Artery Graft for Chronic Total Occlusion of Left Anterior Descending Artery
• The 5-HT_1A Receptor Agonist 8-Hydroxy-2-di-n-(propylamino)tetralin(8-OH-DPAT)Induces Hyperglucagonemia in Rats
• Tunneling Effect in Antioxidant Reaction of Flavonoid
• Kinetic Study on the Free Radical-Scavenging and Vitamin E-Regenerating Actions of Caffeic Acid and Its Related Compounds
• Kinetic Study of the Mechanism of Free-Radical Scavenging Action in Curcumin : Effects of Solvent and pH
• A CIDEP Study on the Photosensitized Reaction of Maleimide with Xanthone: Addition Effect of Hydrochloric Acid
• Experimental Check of Heisenberg Chain Quantum Statistics for a Ferromagnetic Organic Radical Crystal
• Formation and Decay Dynamics of Vitamin E Radical in the Antioxidant Reaction of Vitamin E
• Magnetic Susceptibility of Yang's a Biradical from 4.2 to 293°K
• Kinetics of Vitamin E Regeneration by Water-Soluble Antioxidants in Micellar Dispersions
• Anomaly in the X-T Curve of Galvinoxyl Radical
• Paramagnetic Semiconductors : Hybrid Molecular Materials Based on Ethyl- and Methyl-pyridinium-Substituted Verdazyl Radical Cations and the Ni(dmit)_2 Anion (dmit= 1,3-Dithiol-2-thione-4,5-dithiolate)
• Magnetic Property of Verdazyl Radical Alloy,(p-CDpOV)_ (p-BDpOV)_x.Doping Effect of Magnetic Impurities on Quasi-One Dimensional Heisenberg Organic Ferromagnet (p-CDpOV) and Antiferromagnet (p-BDpOV) with S=1/2
• A DYNAMICAL PROFILE OF METAL INCORPORATION TO A LIPOSOMAL MEMBRANE AS STUDIED BY ELECTROM SPIN RESONANCE
• Excited High-Spin Quartet (S=3/2) State of a Novel π-Conjugated Organic Spin System, Pyrene-Verdazyl Radical
• Kinetic Study of Radical-Scavenging and Vitamin E-Regenerating Actions of Edaravone (3-Methyl-1-phenyl-2-pyrazolin-5-one)
• Long-term results of second-stage thoracic endovascular aortic repair following total aortic arch replacement
• Hybrid Procedures Combining Conventional and Thoracic Endovascular Aortic Repair for Thoracic Aortic Aneurysms
• High-Field Magnetization Study of the Doping Effect of Magnetic Impurity on the Organic Spin-Peierls System: $p$-CyDOV Radical Crystal
• The ESR and ENDOR spectra of the [2.2](2,7)pyrenophane anion radical.
• Kinetic studies of antioxidant activity of new tocopherol model compounds in solution.
• Stopped-flow investigation of antioxidant activity of tocopherols.
• ESR Studies of the Cation Radicals Produced by SbCl5 Oxidation of Some Biphenyls with ortho- and para-Dialkyl Substituents
• Effects of serotonin on blood glucose and insulin levels of glucose- and streptozotocin-treated mice.
• Stabilization energy and spin distribution in pyrenophane cation radicals.
• ESR Study of Spin-Spin Interactions in Verdazyl Biradicals. II
• ENDOR studies of the complexation reaction between spin-labeled crown ether and alkali metal salts.
• ESR and ENDOR studies of cation radicals derived from benzodipyran compounds. Structure and dynamic behavior of heterocyclic ring in tocopherol (vitamin E).
• ENDOR studies on low-symmetry triphenylmethyl with ortho or para-methoxy substituents.
• ENDOR studies of the hyperfine interaction of phenylgalvinoxyl radicals in solution.
• ESR spectra of radical ions generated from 5,10-dihydroindeno(2,1-a)indene.
• Optical spectra of tocopheroxyl model radicals.
• ESR 13C Hyperfine Structures of the Meta-substituted t-Butyl Biphenyl Anion Radical
• Carbon-13 Nuclear Magnetic Resonance Studies of Biphenyl Derivatives II. FT–NMR of Halobiphenyls
• Synthesis of trans-Dibromo-bis{(2-pyridyl)methylamine} and -bis {S-1-(2-pyridyl)ethylamine} cobalt(III) Complexes
• Spin label investigation of the crown ether. Complex formation between the veratrole analogue of phenoxyl-labeled benzo-15-crown-5 and alkali and alkaline earth metal salts in frozen solution.
• The Effects of the Serotonin1A Receptor Agonist Buspirone on the Blood Glucose and Pancreatic Hormones in Rats.
• Experimental Studies on Characteristics of Pressure Attenuation and Recovery to Saturation for Decompressive Disturbances in Low Pressurized Water
• The dynamical behavior of the sodium cation in some crown ether-Na+-TCNE- ternary complexes as studied by ESR.
• Anomalous Magnetic Properties of Crystalline Galvinoxyl Radical. IV. Effect of the Deuterium Substituent
• ESR Investigation of alkali metal complexes of galvinoxyl-labeled benzo-15-crown-5 in frozen solution.
• The Magnetic Properties of Verdazyl Free Radicals. VI. ESR Studies of Pairs and Triadst of the Symmetrical Triphenylverdazyl Radical in the 1,3,5-Triphenylbenzene Matrix
• Copper(II)-Rare Earth(III)(Ln=La,Gd,Lu) Binuclear Complexes of Bis(2-(3-carboxysalicylidene)aminoethyl)amine: Characterization and Specific Binding of Amino Alcohols.
• Carbon-13 Magnetic Resonance Chemical Shifts in Alkylbiphenyls
• ESR Studies of the Negative Ions of Biphenyl Derivatives. IV. Conformation of 4,4′-Polymethylenebiphenyl Anion Radicals
• ENDOR Studies on the Hindered Alkylbiphenyl Anion Radicals
• ENDOR Studies in the Conformation of 3,3′- or 3,4′-Polymethylenebiphenyl Anion Radicals.
• ESR and ENDOR studies of the hindered internal rotation of higher alkyl groups. 2,6-Di-t-butyl-4-alkylphenoxyl radicals.
• ESR studies of temperature dependent zero-field splitting in yang's biradical.
• Bypass vs. Endovascular Therapy of Infrapopliteal Lesions for Critical Limb Ischemia

もっと見る 閉じる

スポンサーリンク