POSSIBLE ROLE OF IgE-CONSTITUENT CARBOHYDRATE IN THE MEDIATION OF HISTAMINE RELEASE
スポンサーリンク
概要
- 論文の詳細を見る
A possible role of IgE-constituent carbohydrate in the mediation of histamine release was pharmacologically studied in isolated peritoneal rat mast cells. Among polysaccharides obtained commercially, mannan and dextran induced histamine release, and the ED50 was 4 μg/ml and 52 μg/ml, respectively. At doses higher than 1 mg/ml, Ficoll, hyaluronic acid and heparin induced the release, while agarose did not. The weak histamine releasing polysaccharides did not induce inhibition of the dextran-induced histamine release. Monosaccharides such as N-acetylglucosamine, mannose and N-acetylneuraminic acid induced marked inhibition of the mannan-induced histamine release, although other carbohydrate constituents of IgE fucose and galactose were weak inhibitors. The antagonism of the monosaccharides against polysaccharide-induced histamine release was found to be a competitive type. Also, antigen-induced histamine release from peritoneal mast cells actively immunized with egg albumin appeared to be inhibited competitively by a carbohydrate constituent of IgE N-acetylglucosamine. Hence it appears that IgE-constituent carbohydrate may play an important role in IgE-mediated histamine release.
- 社団法人 日本薬理学会の論文
著者
-
Waki Isami
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences
-
Kimura Masayasu
Deparment Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
-
WAKI Isami
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
関連論文
- Effect of Ischemic Preconditioning and Mitochondrial K_ Channel Openers on Chronic Left Ventricular Remodeling in the Ischemic-Reperfused Rat Heart
- Evaluation of Left Atrial Function by the Functional Volume Change Curve Derived From Doppler Flow Spectra
- DESENSITIZING NEUROMUSCULAR BLOCKADE BY p-PHENYLENE-POLYMETHYLENE BIS-AMMONIUM COMPOUNDS DEVELOPED FROM SUCCINYLCHOLINE
- Inhibitory Effect of Magnosalin Derived from Flos magnoliae on Tube Formation of Rat Vascular Endothelial Cells during the Angiogenic Process
- The Diabetic State Increases the Activity but Not the Number of Peritoneal Macrophages in the GK Rat Promoting the Tube Formation of Cultured Endothelial Cells in Rat Aorta
- Suppression by High Glucose Concentration of Insulin Receptor Up-Regulation in Diaphragm and Flexor Digitorum Brevis Muscles from Diabetic KK-CA^y and Streptozotocin-Diabetic Mice
- Diabetic State-Induced Modification of Insulin-Stimulated, Glucose Uptake into and Kinase Activity in, the Diaphragm Muscle of Genetically Diabetic KK-CA^y Mice
- Perspective of Phospholipase A_2 involved in Acetylcholine Receptor Cluster Formation of Mouse Myotubes co-cultured with Spinal Cord Explant
- COMPARISON OF MECHANISMS OF ACTIONS BETWEEN CHOLECYSTOKININ AND PAPAVERINE FOR RELAXING A SPHINCTER OF ODDI IN HOG
- IMMUNOCHEMICAL EVIDENCE FOR INTERACTION BETWEEN CHOLECYSTOKININ C-TERMINAL PEPTIDES AND THE PROTEIN INHIBITOR OF ADENOSINE 3', 5'-CYCLIC MONOPHOSPHATE DEPENDENT PROTEIN KINASE IN HOG TERMINAL BILE DUCTS
- Competence Effect of Basic Fibroblast Growth Factor on Cell Cycle in Subcultured Endothelial Cells of Rat Aorta by Flow Cytometry
- Inhibitory Effects of Traditional Chinese Medicine Shimotsu-to and Its Included Crude Fractions on Adjuvant-Induced Chronic Inflammation of Mice
- Combined Potentiating Effects of Byako-ka-ninjin-to, Its Constituents, Rhizomes of Anemarrhena asphodeloides, Timosaponin A-III, and Calcium on Pilocarpine-Induced Salvia Secretion in Streptozocin-Diabetic Mice
- The Streptozocin-Diabetic State Depresses Saliva Secretion Stimulated by Pilocarpine and Noradrenaline in Mice
- INVOLVEMENT OF GLUCOCORTICOID IN INSULIN-INDUCED ANGIOGENESIS OF ADJUVANT POUCH GRANULOMA IN DIABETIC MICE
- QUANTITATIVE METHOD FOR MEASURING ADJUVANT-INDUCED GRANULOMA ANGIOGENESIS IN INSULIN-TREATED DIABETIC MICE
- MOUSE GRANULOMA POUCH INDUCED BY FREUND'S COMPLETE ADJUVANT WITH CROTON OIL
- Aconitine, a Main Component of Aconite, Increases Spontaneous Acetylcholine Release from the Frontal Cerebral Cortex of Freely Moving Rats
- ACETYLCHOLINE RECEPTOR-OPERATED INTRACELLULAR CALCIUM MOBILIZATION MODIFIED BY DIABETIC STATE IN SKELETAL MUSCLE
- DEVELOPMENTALLY DELAYED SENSITIVITY OF ACETYLCHOLINE RECEPTOR IN MYOTUBES OF NERVE-MUSCLE COCULTURES FROM GENETICALLY DIABETIC MOUSE EMBRYOS
- HYPERSENSITIVITY OF ACETYLCHOLINE RECEPTOR IN DIABETIC SKELETAL MUSCLE TO NEUROMUSCULAR BLOCKERS : THE EFFECT ON MYOTUBES CULTURED WITH SPINAL CORD OR ITS EXTRACT
- Chemical Structural Requirement in Gingerol Derivatives for Potentiation of Prostaglandin F_-Induced Contraction in Isolated Mesenteric Veins of Mice
- The Essential Amino Acid Domains in Salivary Peptide P-C That Potentiate Glucose-Induced Insulin Release and Inhibit Arginine-Induced Glucagon Release from Perfused Rat Pancreas
- Salivary Peptide P-C Potentiates Insulin Release and Inhibits Glucagon Release from Isolated Perfused Pancreas of the Diabetic GK Rat
- Complementary Effects of Paeoniflorin and Glycyrrhizin on Intracellular Ca^ Mobilization in the Nerve - Stimulated Skeletal Muscle of Mice
- PJ-337 Radial artery spasm is an important factor for the radial artery injury after transradial intervention (TRI) : An IVUS study(Peripheral Circulation/Vascular Disease 2(H) : PJ56)(Poster Session (Japanese))
- Potentiation by Higenamine of the Aconitine-Induced Positive Chronotropic Effect in Isolated Right Atria of Mice : The Effects of Cholera Toxin, Forskolin and Pertussis Toxin
- EFFECTS OF A HYPOGLYCEMIC COMPONENT OF GINSENG RADIX ON INSULIN BIOSYNTHESIS IN NORMAL AND DIABETIC ANIMALS
- THE PATTERN OF ACTION OF BLENDED CHINESE TRADITIONAL MEDICINES TO GLUCOSE TOLERANCE CURVES IN GENETICALLY DIABETIC KK-CA^y MICE
- OUABAIN-SENSITIVE INSULIN STIMULATION OF ION AND GLUCOSE TRANSPORT IN RAT VENTRICULAR SLICES
- The Acetylcholine-Hypersensitive Model of Diabetic KK-CA^y Mice Analyzed with Pulse Rate, and Modified by Repeated Cold Stress and by Adrenalectomy
- The effects of peripherally or centrally administered cholecystokinin octapeptide and its antagonist on ambulatory locomotion in mice
- RELAXATION MECHANISMS AND THEIR INHIBITION BY CCK-C-TERMINAL FRAGMENTS AND PROGLUMIDE-PEPTIDES IN BILE DUCT AMPULLA OR DUODENAL CIRCULAR MUSCLES OF HOG
- PHARMACOLOGICAL SEQUENTIAL TRIALS FOR THE FRACTIONATION OF COMPONENTS WITH HYPOGLYCEMIC ACTIVITY IN ALLOXAN DIABETIC MICE FROM GINSENG RADIX
- INHIBITORY EFFECT OF MOLECULAR MOIETY IN PAPAVERINE STRUCTURE ON CYCLIC AMP-PHOSPHODIESTERASE OF SMOOTH AND CARDIAC MUSCLES
- EFFECTS OF HYPOGLYCEMIC COMPONENTS IN GINSENG RADIX ON BLOOD INSULIN LEVEL IN ALLOXAN DIABETIC MICE AND ON INSULIN RELEASE FROM PERFUSED RAT PANCREAS
- A Genetically Diabetic Model “KK-CAy Mice” for a Pharmacological Assay
- INHIBITION OF COMPOUND 48/80-MEDIATED HISTAMINE RELEASE FROM ISOLATED RAT MAST CELLS BY OOSPONOL-RELATED COMPOUNDS (4-ACYL-ISOCOUMARINS)
- RELATIONSHIP BETWEEN SUPERSENSITIVITY TO ACETYLCHOLINE AND PROTEIN SYNTHESIS IN DENERVATED RAT DIAPHRAGM MUSCLES
- EFFECT OF 4-ACYL-ISOCOUMARINS ON IgE-MEDIATED AND MANNAN-INDUCED HISTAMINE RELEASE FROM ISOLATED RAT MAST CELLS
- DIFFERENCE BETWEEN ADRENERGIC β1- AND β2-BLOCKING EFFECTS ON ISOPROTERENOL-INDUCED Ca SPIKE SUPPRESSION IN GUINEA-PIG TAENIA COLI
- THE MODE OF ACTION OF CONTRACTILE EFFECTS INDUCED BY EXTERNAL CALCIUM AND ITS RELATED BIVALENT CATIONS IN THE KCl-DEPOLARIZED RAT UTERUS
- POSSIBLE ROLE OF IgE-CONSTITUENT CARBOHYDRATE IN THE MEDIATION OF HISTAMINE RELEASE
- FLUCTUATION OF ACETYLCHOLINE SENSITIVITY IN SKELETAL MUSCLES WITH DEVELOPMENT, DENERVATION AND GLYCEROL TREATMENT
- DECREASING EFFECTS OF GLYCEROL-FRACTIONS EXTRACTED FROM OX DIAPHRAGM MUSCLES ON ACETYLCHOLINE-INDUCED CONTRACTIONS OF SMOOTH MUSCLES
- Loxiglumide, L - 364,718 and L - 365,260 Prevent the Inhibition of Spontaneous Acetylcholine Release from the Frontal Cerecral Cortex of Freely Moving Rat Peripherally Administered with Cholecystokinin - 8S
- Chemical Structure-Activity of Cnidium Rhizome-Derived Phthalides for the Competence Inhibition of Proliferation in Primary Cultures of Mouse Aorta Smooth Muscle Cells.
- Antiproliferative Effects of the Traditional Chinese Medicine Shimotsu-To, Its Component Cnidium Rhizome and Derived Compounds on Primary Cultures of Mouse Aorta Smooth Muscle Cells.
- Suppression of spontaneous calcium spikes and contraction in isolated portal veins of mice by gingerols and chemically related compounds.
- Inotropic effects of (.+-.)-higenamine and its chemically related components, (+)-R-coclaurine and (+)-S-reticuline, contained in the traditional Sino-Japanese medicines "Bushi" and "Shin-i" in isolated guinea pig papillary muscle.
- Diabetes mellitus-induced hypersensitivity of mouse skeletal muscles to acetylcholine and succinylcholine.
- Hypaconitine, the dominant constituent responsible for the neuromuscular blocking action of the Japanese-sino medicine "bushi" (aconite root).
- Depolarizing effects of glycyrrhizin-derivatives relating to the blend effects with paeoniflorin in mouse diaphragm muscle.
- Blocking effects of blended paeoniflorin or its related compounds with glycyrrhizin on neuromuscular junctions in frog and mouse.
- Diabetic GK Rat Plasma but Not Normal Wistar Rat Plasma Induces Insulin-Stimulated DNA Synthesis in Primary Cultured Smooth Muscle Cells in GK Rat Aorta.
- Platelet-Derived Growth Factor (PDGF) Accelerates Induction of Competence, and Heparin Does Not Inhibit PDGF-Induced Competence in Primary Cultured Smooth Muscle Cells of Rat Aorta.
- Increase in the activities of plasma pseudocholinesterase dependent on the blood glucose level and its relation to the hypersensitivity to acetylcholine in striated muscles of KK-Cay mice with diabetes.
- Blocking effects of a new component, paeoniflorigenone, in paeony root on neuromuscular junctions of frogs and mice.
- Reversed effects between crude and processed ginger extracts on PGF2.ALPHA.-induced contraction in mouse mesenteric veins.
- External Ca2+-dependent Ca2+ release in directly stimulated diaphragm muscles of mice.
- Effects of pollen-extract components, diamines and derivatives of feruloylputrescine on isolated bladder and urethral smooth muscles of mice.
- Succinylcholine-Induced Acceleration and Suppression of Electrically Evoked Acetylcholine Release from Mouse Phrenic Nerve-Hemidiaphragm Muscle Preparation.
- Tetrodotoxin sensitivity of high K+-induced 86Rb efflux in the duodenal circular muscle of pigs.
- Alloxan-diabetic state-induced suppression of Ca2+-dependent slow action potentials in mouse diaphragm muscle.
- Diabetes Mellitus-Induced Enhancement of Prostaglandin F2.ALPHA.-Responses Is Inhibited by Lipoxygenase- but Not Cyclooxygenase-Inhibitors in Mesenteric Veins and Arteries of Mouse and Rat.
- Intracellular Ca2+ and Mg2+ Regulation for Insulin-Stimulated Glucose Uptake into Mouse Diaphragm Muscles.
- Salivary peptide P-C modulates both insulin and glucagon release from isolated perfused rat pancreas.
- Inhibitory Effects of Magnoshinin and Magnosalin, Compounds from "Shin-i" (Flos Magnoliae), on the Competence and Progression Phases in Proliferation of Subcultured Rat Aortic Endothelial Cells.
- Dependence of Cholecystokinin-8-Stimulated Insulin Release on High Glucose Levels Is Evidenced by Pseudo-.ALPHA.-D-Glucose in Rat Pancreas and Islets.
- Depolarizing neuromuscular blocking action induced by electropharmacological coupling in the combined effect of paeoniflorin and glycyrrhizin.
- .BETA.-Eudesmol (a main component of Atractylodes lancea)-induced potentiation of depolarizing neuromuscular blockade in diaphragm muscles of normal and diabetic mice.
- The External Ca2+-Dependence of Acetylcholine-Induced Contracture in Single Innervated and Denervated Skeletal Muscle Cells in Mice.
- Heparin Inhibits the Progression Phase of Subcultured Endothelial Cell Proliferation in Rat Aorta.